XEN907 [Ligand Id: 5732] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1780061
  • Nav1.7/Sodium channel protein type IX alpha subunit in Human [ChEMBL: CHEMBL4296] [GtoPdb: 584] [UniProtKB: Q15858]
  • This target only has 0 pki data point
1 CHEMBL1780061_lig_chart_1 Sodium channel protein type IX alpha subunit Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Nav1.7/Sodium channel protein type IX alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4296] [GtoPdb: 584] [UniProtKB: Q15858]
GtoPdb [14C]guanidinium influx - 8.5 pIC50 3 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 3676-81 [PMID:21570288]
ChEMBL Inhibition of human NaV1.7 expressed in HEK293 cells by [14C]guanidinium influx assay B 8.52 pIC50 3 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 3676-3681 [PMID:21570288]
ChEMBL Inhibition of Homo sapiens (human) NaV1.7 expressed in HEK293 cells assessed as decrease in [14C]guanidinium influx after 2 hr by liquid scintillation counting analysis B 8.52 pIC50 3 nM IC50 Med Chem Res (2013) 22: 1825-1836

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]