SB 218795 [Ligand Id: 5764] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL9843 (SB-218795)
  • NK1 receptor/Neurokinin 1 receptor in Human [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103]
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  • NK2 receptor/Neurokinin 2 receptor in Human [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452]
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  • NK3 receptor/Neurokinin 3 receptor in Human [ChEMBL: CHEMBL4429] [GtoPdb: 362] [UniProtKB: P29371]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103]
ChEMBL Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8) B 4 pKi >100000 nM Ki J. Med. Chem. (1996) 39: 2281-2284 [PMID:8691422]
ChEMBL Inhibition of [3H]-substance P binding in human Tachykinin receptor 1 of chinese hamster ovary (hNK-1-CHO) cell membranes B 4 pKi >100000 nM Ki J. Med. Chem. (1997) 40: 1794-1807 [PMID:9191956]
NK2 receptor/Neurokinin 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452]
ChEMBL Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8) B 5.08 pKi 8333 nM Ki J. Med. Chem. (1996) 39: 2281-2284 [PMID:8691422]
ChEMBL Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes. B 5.91 pKi 1221 nM Ki J. Med. Chem. (1997) 40: 1794-1807 [PMID:9191956]
NK3 receptor/Neurokinin 3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4429] [GtoPdb: 362] [UniProtKB: P29371]
ChEMBL Binding Affinity of [125I]-MePhe7-NKB towards Tachykinin receptor 3-CHO cell membranes(n=3-8) B 6.03 pKi 925 nM Ki J. Med. Chem. (1996) 39: 2281-2284 [PMID:8691422]
ChEMBL Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes. B 7.89 pKi 13 nM Ki J. Med. Chem. (1997) 40: 1794-1807 [PMID:9191956]
ChEMBL Binding affinity towards cloned human Tachykinin receptor 3 (hNK-3) expressed in CHO cells using [125I][MePhe7]-NKB B 7.89 pKi 13 nM Ki J. Med. Chem. (1999) 42: 1053-1065 [PMID:10090788]
GtoPdb - - 7.97 pKi 10.6 nM Ki J. Med. Chem. (1996) 39: 2281-4 [PMID:8691422]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay F 4.9 pIC50 12589.25 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay F 4.9 pIC50 12589.25 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]