compound 21 [PMID: 21185185] [Ligand Id: 5789] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1770358 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4] | ||||||||
| GtoPdb | - | - | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2721-4 [PMID:21185185] |
| ChEMBL | Displacement of [3H]nicotinic acid from human GPR109A receptor | B | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2721-2724 [PMID:21185185] |
| ChEMBL | Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay | F | 6.67 | pEC50 | 214 | nM | EC50 | Bioorg Med Chem Lett (2011) 21: 2721-2724 [PMID:21185185] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
