D-phenylalanine [Ligand Id: 5797] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL379630
  • L-type amino acid transporter 1 in Human [ChEMBL: CHEMBL4459] [GtoPdb: 896] [UniProtKB: Q01650]
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  • HCA3 receptor in Human [GtoPdb: 313] [UniProtKB: P49019]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
L-type amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4459] [GtoPdb: 896] [UniProtKB: Q01650]
ChEMBL Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis relative to BCH B 4.34 pIC50 46000 nM IC50 J Med Chem (2018) 61: 7358-7373 [PMID:30048132]
HCA3 receptor in Human [GtoPdb: 313] [UniProtKB: P49019]
GtoPdb - - 5.04 pEC50 9020 nM EC50 Proc. Natl. Acad. Sci. U.S.A. (2009) 106: 3930-4 [PMID:19237584]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]