compound 6o [PMID: 19524438] [Ligand Id: 5800] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL564300
  • HCA3 receptor/HM74 nicotinic acid GPCR in Human [ChEMBL: CHEMBL4421] [GtoPdb: 313] [UniProtKB: P49019]
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  • HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
HCA3 receptor/HM74 nicotinic acid GPCR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4421] [GtoPdb: 313] [UniProtKB: P49019]
ChEMBL Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay F 8.5 pEC50 3.16 nM EC50 Bioorg. Med. Chem. Lett. (2009) 19: 4207-4209 [PMID:19524438]
GtoPdb - - 8.52 pEC50 3 nM EC50 Bioorg Med Chem Lett (2009) 19: 4207-9 [PMID:19524438]
HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
ChEMBL Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay F 5.04 pEC50 9120.11 nM EC50 Bioorg. Med. Chem. Lett. (2009) 19: 4207-4209 [PMID:19524438]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]