ChEMBL ligand: CHEMBL1210313
NPS receptor/Neuropeptide S receptor in Human [ChEMBL: CHEMBL5162] [GtoPdb: 302] [UniProtKB: Q6W5P4] NPS receptor/Neuropeptide S receptor in Rat [ChEMBL: CHEMBL3308949] [GtoPdb: 302] [UniProtKB: P0C0L6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
NPS receptor/Neuropeptide S receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5162] [GtoPdb: 302] [UniProtKB: Q6W5P4]
ChEMBL	Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay	F	6.11	pIC50	785	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4700-4703 [PMID:20510609]
ChEMBL	Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay	F	7.26	pIC50	55	nM	IC50	J Med Chem (2013) 56: 9045-9056 [PMID:24171469]
ChEMBL	Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay	F	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4700-4703 [PMID:20510609]
ChEMBL	Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay	B	7.96	pIC50	11	nM	IC50	J Med Chem (2013) 56: 9045-9056 [PMID:24171469]
GtoPdb	-	-	8	pIC50	-	-	-	Bioorg Med Chem Lett (2010) 20: 4700-3 [PMID:20510609]
ChEMBL	Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay	F	8	pIC50	10	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4700-4703 [PMID:20510609]
ChEMBL	Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay	F	8	pIC50	10	nM	IC50	J Med Chem (2013) 56: 9045-9056 [PMID:24171469]
ChEMBL	Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation counting	B	8.17	pIC50	6.7	nM	IC50	J Med Chem (2013) 56: 9045-9056 [PMID:24171469]
ChEMBL	Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)	B	8.89	pIC50	1.3	nM	IC50	J Med Chem (2013) 56: 9045-9056 [PMID:24171469]
ChEMBL	Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay	F	8.92	pIC50	1.2	nM	IC50	J Med Chem (2013) 56: 9045-9056 [PMID:24171469]
NPS receptor/Neuropeptide S receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308949] [GtoPdb: 302] [UniProtKB: P0C0L6]
ChEMBL	Displacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 mins	B	5.84	pIC50	1440	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4700-4703 [PMID:20510609]
ChEMBL	Displacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 mins	B	5.85	pEC50	1400	nM	EC50	Bioorg Med Chem Lett (2010) 20: 4700-4703 [PMID:20510609]
ChEMBL	Displacement of [3H]quinolinone from rat NPS receptor	B	8.89	pEC50	1.3	nM	EC50	Bioorg Med Chem Lett (2010) 20: 4700-4703 [PMID:20510609]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]