PF-04418948 [Ligand Id: 5817] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3286797 (Pf-04418948)
  • BLT1 receptor/Leukotriene B4 receptor 1 in Human [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722]
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  • EP2 receptor/Prostanoid EP2 receptor in Human [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
  • EP2 receptor in Mouse [GtoPdb: 341] [UniProtKB: Q62053]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
BLT1 receptor/Leukotriene B4 receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722]
ChEMBL LTB4 (h) (BLT1) CEREP ligand profiling B 5.32 pKi 4800 nM Ki Data for DCP probe PF-04418948
ChEMBL LTB4 (h) (BLT1) CEREP ligand profiling B 5.01 pIC50 9700 nM IC50 Data for DCP probe PF-04418948
EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
ChEMBL Inhibition of binding to PTGER2 B 8.3 pIC50 5 nM IC50 Data for DCP probe PF-04418948
EP2 receptor in Mouse [GtoPdb: 341] [UniProtKB: Q62053]
Quinone reductase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3959] [UniProtKB: P16083]
ChEMBL ML2 (MT3) CEREP ligand profiling B 6.28 pKi 520 nM Ki Data for DCP probe PF-04418948
ChEMBL ML2 (MT3) CEREP ligand profiling B 6.28 pIC50 530 nM IC50 Data for DCP probe PF-04418948

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]