FK-788 [Ligand Id: 5855] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL196779 (FK-788)
  • DP1 receptor/Prostanoid DP receptor in Human [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258]
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  • EP1 receptor/Prostanoid EP1 receptor in Human [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
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  • EP2 receptor/Prostanoid EP2 receptor in Human [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
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  • EP3 receptor/Prostanoid EP3 receptor in Human [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
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  • EP4 receptor/Prostanoid EP4 receptor in Human [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
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  • FP receptor/Prostanoid FP receptor in Human [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088]
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  • IP receptor/Prostanoid IP receptor in Human [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
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  • TP receptor/Thromboxane A2 receptor in Human [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258]
ChEMBL Displacement of [3H]PGD-2 from human Prostanoid DP receptor B 5.64 pKi 2300 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 3091-3095 [PMID:15914004]
EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
ChEMBL Displacement of [3H]PGE-2 from human Prostanoid EP1 receptor B 5.02 pKi 9600 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 3091-3095 [PMID:15914004]
EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
ChEMBL Displacement of [3H]-PGE-2 from human Prostanoid EP2 receptor B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 3091-3095 [PMID:15914004]
EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
ChEMBL Displacement of [3H]PGE-2 from human Prostanoid EP3 receptor B 5.09 pKi 8200 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 3091-3095 [PMID:15914004]
EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
ChEMBL Displacement of [3H]PGE-2 from human Prostanoid EP4 receptor B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 3091-3095 [PMID:15914004]
FP receptor/Prostanoid FP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088]
ChEMBL Displacement of [3H]PGF-2 from human Prostanoid FP receptor B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 3091-3095 [PMID:15914004]
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
GtoPdb - - 8.05 pKi - - - Bioorg. Med. Chem. Lett. (2005) 15: 3091-5 [PMID:15914004]
ChEMBL Displacement of [3H]iloprost from human Prostanoid IP receptor B 8.05 pKi 8.9 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 3091-3095 [PMID:15914004]
TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
ChEMBL Displacement of [3H]SQ-29,548 from human Prostanoid TP receptor B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 3091-3095 [PMID:15914004]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]