aurora kinase inhibitor II [Ligand Id: 5930] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL382590 (Anilinoquinazoline1)
  • aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
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  • aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL Inhibitory activity against Aurora A B 6.41 pIC50 393 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 1320-1323 [PMID:16337122]
ChEMBL Inhibition of Aurora A B 6.41 pIC50 393 nM IC50 J. Med. Chem. (2006) 49: 4805-4808 [PMID:16884290]
ChEMBL Inhibition of Aurora kinase A B 6.51 pIC50 310 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
GtoPdb - - 6.51 pIC50 310 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-8 [PMID:18077363]
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
GtoPdb - - 5.9 pIC50 1250 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-8 [PMID:18077363]
ChEMBL Inhibition of Aurora kinase B in MCF7 cells B 5.9 pIC50 1250 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]

ChEMBL data shown on this page come from version 25:

A.P. Bento, A. Gaulton, A. Hersey, et al. (2014). The ChEMBL bioactivity database: an update. Nucl. Acids Res. Database Issue. 42 D1083-D1090. [PMID:24214965]