Cdk/Crk inhibitor [Ligand Id: 5943] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL258721 (RGB-286147)
  • cyclin dependent kinase 6/CDK6/cyclin D3 in Human [ChEMBL: CHEMBL2111448] [GtoPdb: 1978] [UniProtKB: P30281Q00534]
  • This target only has 0 pki data point
1 CHEMBL258721_lig_chart_1 CDK6/cyclin D3 Human
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 7/Cyclin-dependent kinase 7/ cyclin H in Human [ChEMBL: CHEMBL2111288] [GtoPdb: 1979] [UniProtKB: P50613P51946]
  • This target only has 0 pki data point
2 CHEMBL258721_lig_chart_2 Cyclin-dependent kinase 7/ cyclin H Human
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750]
  • This target only has 0 pki data point
3 CHEMBL258721_lig_chart_3 Cyclin-dependent kinase 9 Human
There should be some charts here, you may need to enable JavaScript!
  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
  • This target only has 0 pki data point
4 CHEMBL258721_lig_chart_4 Glycogen synthase kinase-3 beta Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 6/CDK6/cyclin D3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111448] [GtoPdb: 1978] [UniProtKB: P30281Q00534]
ChEMBL Inhibition of Cdk6/cyclin D3 B 6.55 pIC50 282 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
GtoPdb CDK6/cyclin D3 complex - 6.55 pIC50 282 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-8 [PMID:18077363]
cyclin dependent kinase 7/Cyclin-dependent kinase 7/ cyclin H in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111288] [GtoPdb: 1979] [UniProtKB: P50613P51946]
ChEMBL Inhibition of Cdk7/H/MAT1 B 7.15 pIC50 71 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
GtoPdb CDK7/cyclin H - 7.15 pIC50 71 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-8 [PMID:18077363]
cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750]
ChEMBL Inhibition of Cdk9 B 8.05 pIC50 9 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
GtoPdb - - 6.12 pIC50 754 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-8 [PMID:18077363]
ChEMBL Inhibition of GSK3-beta B 6.12 pIC50 754 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]