ChEMBL ligand: CHEMBL1802728
aurora kinase A in Human [GtoPdb: 1936] [UniProtKB: O14965] There should be some charts here, you may need to enable JavaScript!
aurora kinase B in Human [GtoPdb: 1937] [UniProtKB: Q96GD4] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2 in Human [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 4 in Human [GtoPdb: 1976] [UniProtKB: P11802] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 7 in Human [GtoPdb: 1979] [UniProtKB: P50613] There should be some charts here, you may need to enable JavaScript!
eukaryotic translation initiation factor 2 alpha kinase 2 in Human [GtoPdb: 2016] [UniProtKB: P19525] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
aurora kinase A in Human [GtoPdb: 1936] [UniProtKB: O14965]
GtoPdb	-	-	7.17	pIC50	67	nM	IC50	J Med Chem (2018) 61: 9105-9120 [PMID:30234987]
aurora kinase B in Human [GtoPdb: 1937] [UniProtKB: Q96GD4]
GtoPdb	-	-	7.46	pIC50	35	nM	IC50	J Med Chem (2018) 61: 9105-9120 [PMID:30234987]
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
GtoPdb	CDK1/cyclin B complex used in assay	-	5.18	pIC50	6600	nM	IC50	Mol Cancer Ther (2005) 4: 1328-37 [PMID:16170024]
cyclin dependent kinase 2 in Human [GtoPdb: 1973] [UniProtKB: P24941]
GtoPdb	CDK2/cyclin A complex used in assay	-	6.39	pIC50	410	nM	IC50	Mol Cancer Ther (2005) 4: 1328-37 [PMID:16170024]
GtoPdb	-	-	6.4	pIC50	400	nM	IC50	J Med Chem (2018) 61: 9105-9120 [PMID:30234987]
cyclin dependent kinase 4 in Human [GtoPdb: 1976] [UniProtKB: P11802]
GtoPdb	CDK4/cyclin D complex used in assay	-	5.26	pIC50	5500	nM	IC50	Mol Cancer Ther (2005) 4: 1328-37 [PMID:16170024]
cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535]
GtoPdb	CDK5/p25 complex used in assay	-	4.82	pIC50	15000	nM	IC50	Mol Cancer Ther (2005) 4: 1328-37 [PMID:16170024]
cyclin dependent kinase 7 in Human [GtoPdb: 1979] [UniProtKB: P50613]
GtoPdb	CDK7/cyclin H complex used in assay	-	5.41	pIC50	3900	nM	IC50	Mol Cancer Ther (2005) 4: 1328-37 [PMID:16170024]
eukaryotic translation initiation factor 2 alpha kinase 2 in Human [GtoPdb: 2016] [UniProtKB: P19525]
GtoPdb	-	-	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem Lett (2011) 21: 4108-14 [PMID:21632247]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]