Cdk4 inhibitor II [Ligand Id: 5951] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1331734
  • cyclin dependent kinase 2 in Human [GtoPdb: 1973] [UniProtKB: P24941]
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  • cyclin dependent kinase 4 in Human [GtoPdb: 1976] [UniProtKB: P11802]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 2 in Human [GtoPdb: 1973] [UniProtKB: P24941]
GtoPdb CDK2/cyclin A complex used in assay - 4 pIC50 >100000 nM IC50 Clin. Cancer Res. (1999) 5: 4279-86 [PMID:10632371]
cyclin dependent kinase 4 in Human [GtoPdb: 1976] [UniProtKB: P11802]
GtoPdb CDK4/cyclin D1 complex used in assay - 6.7 pIC50 200 nM IC50 Clin. Cancer Res. (1999) 5: 4279-86 [PMID:10632371]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]