Cdk4 inhibitor III [Ligand Id: 5952] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL290904
  • cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
  • This target only has 0 pki data point
1 CHEMBL290904_lig_chart_1 Cyclin-dependent kinase 4 Human
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  • cyclin dependent kinase 2 in Human [GtoPdb: 1973] [UniProtKB: P24941]
  • This target only has 0 pki data point
2 CHEMBL290904_lig_chart_2 cyclin dependent kinase 2 Human
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  • lysine methyltransferase 5A in Human [GtoPdb: 2704] [UniProtKB: Q9NQR1]
  • This target only has 0 pki data point
3 CHEMBL290904_lig_chart_3 lysine methyltransferase 5A Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
ChEMBL Inhibition of Cyclin-dependent kinase 4 (CDK4/cyclin Dl) B 5.22 pIC50 6000 nM IC50 Bioorg. Med. Chem. Lett. (2000) 10: 461-464 [PMID:10743948]
GtoPdb CDK4/cyclin D1 complex - 8.22 pIC50 6 nM IC50 Bioorg. Med. Chem. Lett. (2000) 10: 461-4 [PMID:10743948]
cyclin dependent kinase 2 in Human [GtoPdb: 1973] [UniProtKB: P24941]
GtoPdb CDK2/cyclin A complex - 6.7 pIC50 >200 nM IC50 Bioorg. Med. Chem. Lett. (2000) 10: 461-4 [PMID:10743948]
lysine methyltransferase 5A in Human [GtoPdb: 2704] [UniProtKB: Q9NQR1]
GtoPdb - - 6.3 pIC50 500 nM IC50 ACS Chem. Biol. (2014) 9: 2471-8 [PMID:25137013]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]