compound 52 [PMID: 9677190] [Ligand Id: 5955] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL311228
  • Cell division control protein 28 in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5213] [UniProtKB: P00546]
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  • Cyclin-dependent protein kinase PHO85 in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5589] [UniProtKB: P17157]
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  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
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  • eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525]
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  • MER proto-oncogene, tyrosine kinase/Proto-oncogene tyrosine-protein kinase MER in Human [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cell division control protein 28 in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5213] [UniProtKB: P00546]
ChEMBL Inhibition of yeast W303 cdc28 phosphorylation assessed as [32P] incorporation in histone H1 from [gamma32P]ATP by scintillation counting B 5.15 pIC50 7000 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493P14635]
ChEMBL Inhibition of human cdc2/cyclin B assessed as [32P] incorporation in histone H1 from [gamma32P]ATP B 6.47 pIC50 340 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
GtoPdb CDK1/cyclin B complex - 6.47 pIC50 340 nM IC50 Science (1998) 281: 533-8 [PMID:9677190]
Cyclin-dependent protein kinase PHO85 in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5589] [UniProtKB: P17157]
ChEMBL Inhibition of yeast W303 Pho85 phosphorylation assessed as [32P] incorporation in histone H1 from [gamma32P]ATP by scintillation counting B 5.7 pIC50 2000 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Binding affinity to GSK3-beta B 6.9 pKd 126 nM Kd Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
GtoPdb - - 7.52 pIC50 30 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-8 [PMID:18077363]
ChEMBL Inhibition of GSK3-beta B 7.52 pIC50 30 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525]
ChEMBL Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay B 4.8 pIC50 16000 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 4108-4114 [PMID:21632247]
MER proto-oncogene, tyrosine kinase/Proto-oncogene tyrosine-protein kinase MER in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866]
ChEMBL Inhibition of Mer kinase B 4.95 pIC50 11300 nM IC50 ACS Med. Chem. Lett. (2011) 2: 907-912 [PMID:22247788]
ChEMBL Inhibition of MER (588 to 855) (unknown origin) by fluorescence assay B 4.95 pIC50 11300 nM IC50 Eur. J. Med. Chem. (2013) 61: 2-25 [PMID:22749189]
ChEMBL Inhibition of N-terminal His-tagged Mer kinase (588 to 855 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells measured every min by ADP Quest Assay B 4.95 pIC50 11300 nM IC50 Bioorg. Med. Chem. (2016) 24: 3083-3092 [PMID:27238842]
ChEMBL Inhibition of Mer expressed in Escherichia coli BL21 (DE3) cells using EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay B 4.96 pIC50 11000 nM IC50 ACS Med. Chem. Lett. (2012) 3: 129-134 [PMID:22662287]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]