GSK-3 inhibitor IX [Ligand Id: 5974] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2178734
  • cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
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  • cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535]
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  • glycogen synthase kinase 3 alpha in Pig [GtoPdb: 2029]
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  • glycogen synthase kinase 3 beta in Pig [GtoPdb: 2030]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
GtoPdb CDK1/cyclin B complex - 6.49 pIC50 320 nM IC50 J Med Chem (2004) 47: 935-46 [PMID:14761195];
Chem Biol (2003) 10: 1255-66 [PMID:14700633]
cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535]
GtoPdb CDK5/p25 complex - 7.08 pIC50 83 nM IC50 J Med Chem (2004) 47: 935-46 [PMID:14761195];
Chem Biol (2003) 10: 1255-66 [PMID:14700633]
glycogen synthase kinase 3 alpha in Pig [GtoPdb: 2029]
GtoPdb GSK3α/β complex from pig brain - 8.3 pIC50 5 nM IC50 J Med Chem (2004) 47: 935-46 [PMID:14761195];
Chem Biol (2003) 10: 1255-66 [PMID:14700633]
glycogen synthase kinase 3 beta in Pig [GtoPdb: 2030]
GtoPdb GSK3α/β complex from pig brain - 8.3 pIC50 5 nM IC50 J Med Chem (2004) 47: 935-46 [PMID:14761195];
Chem Biol (2003) 10: 1255-66 [PMID:14700633]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]