GSK-3 inhibitor IX [Ligand Id: 5974] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2178734
  • cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
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  • cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535]
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  • glycogen synthase kinase 3 alpha in Pig [GtoPdb: 2029]
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  • glycogen synthase kinase 3 beta in Pig [GtoPdb: 2030]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
GtoPdb CDK1/cyclin B complex - 6.49 pIC50 320 nM IC50 J. Med. Chem. (2004) 47: 935-46 [PMID:14761195];
Chem. Biol. (2003) 10: 1255-66 [PMID:14700633]
cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535]
GtoPdb CDK5/p25 complex - 7.08 pIC50 83 nM IC50 J. Med. Chem. (2004) 47: 935-46 [PMID:14761195];
Chem. Biol. (2003) 10: 1255-66 [PMID:14700633]
glycogen synthase kinase 3 alpha in Pig [GtoPdb: 2029]
GtoPdb GSK3α/β complex from pig brain - 8.3 pIC50 5 nM IC50 J. Med. Chem. (2004) 47: 935-46 [PMID:14761195];
Chem. Biol. (2003) 10: 1255-66 [PMID:14700633]
glycogen synthase kinase 3 beta in Pig [GtoPdb: 2030]
GtoPdb GSK3α/β complex from pig brain - 8.3 pIC50 5 nM IC50 J. Med. Chem. (2004) 47: 935-46 [PMID:14761195];
Chem. Biol. (2003) 10: 1255-66 [PMID:14700633]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]