GSK-3 inhibitor X [Ligand Id: 5975] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL430226
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  • cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
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  • glycogen synthase kinase 3 alpha in Pig [GtoPdb: 2029]
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  • glycogen synthase kinase 3 beta in Pig [GtoPdb: 2030]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Aryl hydrocarbon receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3201] [GtoPdb: 2951] [UniProtKB: P35869]
ChEMBL Agonist activity at human aryl hydrocarbon receptor F 6.8 pEC50 160 nM EC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067P06493P14635Q8WWL7]
ChEMBL Inhibitory activity against cyclin dependent kinase 1-cyclinB from starfish (Marthasterias glacialis) oocytes B 4.2 pIC50 63000 nM IC50 J. Med. Chem. (2004) 47: 935-946 [PMID:14761195]
ChEMBL Inhibition of CDK1/cyclinB B 4.2 pIC50 63000 nM IC50 Trends Pharmacol. Sci. (2004) 25: 471-480 [PMID:15559249]
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
ChEMBL Inhibitory activity against Cyclin-dependent kinase 5-p35nck5a B 5.62 pIC50 2400 nM IC50 J. Med. Chem. (2004) 47: 935-946 [PMID:14761195]
glycogen synthase kinase 3 alpha in Pig [GtoPdb: 2029]
GtoPdb Measured using GSK3 as a complex of α and β isozymes, isolated from pig brain - 8 pIC50 10 nM IC50 J Med Chem (2004) 47: 935-46 [PMID:14761195]
glycogen synthase kinase 3 beta in Pig [GtoPdb: 2030]
GtoPdb Measured using GSK3 as a complex of α and β isozymes, isolated from pig brain - 8 pIC50 10 nM IC50 J Med Chem (2004) 47: 935-46 [PMID:14761195]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]