TWS119 [Ligand Id: 5980] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL405759 (TWS-119) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| GtoPdb | - | - | 7.52 | pIC50 | 30 | nM | IC50 | Proc Natl Acad Sci USA (2003) 100: 7632-7 [PMID:12794184] |
| ChEMBL | Inhibition of GSK3-beta | B | 7.52 | pIC50 | 30 | nM | IC50 | Trends Pharmacol Sci (2004) 25: 471-480 [PMID:15559249] |
| ChEMBL | Inhibition of Glycogen synthase kinase-3 beta (unknown origin) | B | 7.52 | pIC50 | 30 | nM | IC50 | Eur J Med Chem (2019) 164: 448-470 [PMID:30616053] |
| ChEMBL | Inhibition of GSK3beta (unknown origin) | B | 7.52 | pIC50 | 30 | nM | IC50 | Eur J Med Chem (2021) 210: 112949-112949 [PMID:33097303] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075321] [GtoPdb: 2030] [UniProtKB: Q9WV60] | ||||||||
| ChEMBL | Inhibition of GSK-3 beta in mouse D3 cells | B | 6.9 | pKd | 126 | nM | Kd | Nat Chem Biol (2005) 1: 74-84 [PMID:16408003] |
| ChEMBL | Binding affinity to GSK-3 beta in mouse D3 cells | B | 7.52 | pIC50 | 30 | nM | IC50 | Nat Chem Biol (2005) 1: 74-84 [PMID:16408003] |
| ChEMBL | Inhibition of GSK-3 beta in mouse D3 cells assessed as induction of neuron specific marker microtubule-associated protein 2 by immunofluorescence method | B | 6 | pEC50 | 1000 | nM | EC50 | Nat Chem Biol (2005) 1: 74-84 [PMID:16408003] |
| ChEMBL | Inhibition of GSK-3 beta in mouse D3 cells assessed as induction of neuron specific marker neurofilament-M by immunofluorescence method | B | 6 | pEC50 | 1000 | nM | EC50 | Nat Chem Biol (2005) 1: 74-84 [PMID:16408003] |
| ChEMBL | Inhibition of GSK-3 beta in mouse D3 cells assessed as induction of neuron specific marker beta3-tubulin by immunofluorescence method | B | 6 | pEC50 | 1000 | nM | EC50 | Nat Chem Biol (2005) 1: 74-84 [PMID:16408003] |
| eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525] | ||||||||
| ChEMBL | Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay | B | 5.4 | pIC50 | 4000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4108-4114 [PMID:21632247] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
