GSK-3beta inhibitor XI [Ligand Id: 5981] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL272629 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| ChEMBL | Inhibition of GSK3beta (unknown origin) | B | 7.6 | pIC50 | 25 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1532-1537 [PMID:24560539] |
| ChEMBL | Inhibition of human GSK3-beta | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem (2008) 16: 636-643 [PMID:18006321] |
| glycogen synthase kinase 3 beta in Rabbit [GtoPdb: 2030] | ||||||||
| GtoPdb | - | - | 7.6 | pKi | 25 | nM | Ki | Bioorg Med Chem (2004) 12: 3167-85 [PMID:15158785] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
