GSK-3beta inhibitor XI [Ligand Id: 5981] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL272629
  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
  • glycogen synthase kinase 3 beta in Rabbit [GtoPdb: 2030]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Inhibition of GSK3beta (unknown origin) B 7.6 pIC50 25 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 1532-1537 [PMID:24560539]
ChEMBL Inhibition of human GSK3-beta B 8.3 pIC50 5 nM IC50 Bioorg. Med. Chem. (2008) 16: 636-643 [PMID:18006321]
glycogen synthase kinase 3 beta in Rabbit [GtoPdb: 2030]
GtoPdb - - 7.6 pKi 25 nM Ki Bioorg Med Chem (2004) 12: 3167-85 [PMID:15158785]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]