IRAK-1/4 inhibitor [Ligand Id: 5990] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL379787
  • interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
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  • interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
GtoPdb - - 6.52 pIC50 300 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 2842-5 [PMID:16563752]
ChEMBL Inhibition of IRAK1 B 6.52 pIC50 300 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 2842-2845 [PMID:16563752]
interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3]
ChEMBL Inhibition of IRAK4 B 6.7 pIC50 200 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 2842-2845 [PMID:16563752]
GtoPdb - - 6.7 pIC50 200 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 2842-5 [PMID:16563752]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]