isogranulatimide [Ligand Id: 5991] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL413188 (Isogranulatimide) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
| ChEMBL | Inhibition of Cdk1 | B | 5 | pIC50 | 10000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527] | ||||||||
| ChEMBL | Inhibition of DNA-PK | B | 5 | pIC50 | 10000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| GtoPdb | - | - | 6.3 | pIC50 | 500 | nM | IC50 |
Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363]; Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189] |
| ChEMBL | Inhibition of GSK3-beta | B | 6.3 | pIC50 | 500 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525] | ||||||||
| ChEMBL | Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay | B | 7 | pIC50 | <100 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4108-4114 [PMID:21632247] |
| checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
| ChEMBL | Inhibition of human Chk1 expressed in Sf9 cells | B | 6.36 | pIC50 | 440 | nM | IC50 | J Med Chem (2007) 50: 4669-4680 [PMID:17722905] |
| ChEMBL | Inhibition of human Chk1 | B | 6.36 | pIC50 | 440 | nM | IC50 | Bioorg Med Chem (2007) 15: 5965-5980 [PMID:17582773] |
| ChEMBL | Inhibition of human Chk1 | B | 6.36 | pIC50 | 440 | nM | IC50 | Eur J Med Chem (2008) 43: 282-292 [PMID:17502122] |
| GtoPdb | - | - | 7 | pIC50 | 100 | nM | IC50 |
Bioorg Med Chem (2008) 16: 4419-30 [PMID:18321713]; Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189] |
| ChEMBL | Inhibition of Chk1 | B | 7 | pIC50 | 100 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| ChEMBL | Inhibition of human Chk1 | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem (2008) 16: 4419-4430 [PMID:18321713] |
| ChEMBL | Inhibition of Chk1 (unknown origin) | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem (2014) 22: 4961-4967 [PMID:25047935] |
| checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017] | ||||||||
| GtoPdb | - | - | 5.52 | pIC50 | 3000 | nM | IC50 | Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363] |
| ChEMBL | Inhibition of Chk2 | B | 5.52 | pIC50 | 3000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
