JAK3 inhibitor II [Ligand Id: 5993] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL473773 (WHI-P154)
  • Janus kinase 1/Tyrosine-protein kinase JAK1 in Human [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458]
  • This target only has 0 pki data point
1 CHEMBL473773_lig_chart_1 Tyrosine-protein kinase JAK1 Human
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  • Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
  • This target only has 0 pki data point
2 CHEMBL473773_lig_chart_2 Tyrosine-protein kinase JAK2 Human
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  • Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
  • This target only has 0 pki data point
3 CHEMBL473773_lig_chart_3 Tyrosine-protein kinase JAK3 Human
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  • epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
  • This target only has 0 pki data point
4 CHEMBL473773_lig_chart_4 epidermal growth factor receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458]
GtoPdb - - 5 pIC50 >10000 nM IC50 Blood (2008) 111: 2155-7 [PMID:18094329]
ChEMBL Inhibition of JAK1 B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
GtoPdb - - 5 pIC50 >10000 nM IC50 Blood (2008) 111: 2155-7 [PMID:18094329]
ChEMBL Inhibition of JAK2 B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
GtoPdb - - 5.74 pIC50 1800 nM IC50 Blood (2008) 111: 2155-7 [PMID:18094329]
ChEMBL Inhibition of JAK3 (unknown origin) B 5.74 pIC50 1800 nM IC50 J Med Chem (2018) 61: 9811-9840 [PMID:29969256]
epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
GtoPdb - - 8.4 pIC50 4 nM IC50 Blood (2008) 111: 2155-7 [PMID:18094329]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]