JAK3 inhibitor IV [Ligand Id: 5994] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL596674
  • Protein-glutamine gamma-glutamyltransferase in Guinea pig [ChEMBL: CHEMBL3308976] [UniProtKB: Q7M0F8]
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  • Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
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  • Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
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  • transglutaminase 2 in Human [GtoPdb: 3015] [UniProtKB: P21980]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Protein-glutamine gamma-glutamyltransferase in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308976] [UniProtKB: Q7M0F8]
ChEMBL Inhibition of guinea pig liver transglutaminase B 5.4 pIC50 4000 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 1141-1144 [PMID:20053561]
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
ChEMBL Inhibition of JAK3 (unknown origin) by ELISA B 7.1 pIC50 80 nM IC50 Bioorg Med Chem Lett (2017) 27: 4229-4237 [PMID:28844493]
GtoPdb - - 7.1 pIC50 79 nM IC50 Bioorg. Med. Chem. Lett. (2000) 10: 575-9 [PMID:10741557]
Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
GtoPdb - - 4.4 pIC50 39810 nM IC50 Bioorg. Med. Chem. Lett. (2000) 10: 575-9 [PMID:10741557]
transglutaminase 2 in Human [GtoPdb: 3015] [UniProtKB: P21980]
GtoPdb In the absence of DTT. - 8 pIC50 10 nM IC50 Chem. Biol. (2008) 15: 969-78 [PMID:18804034]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]