JAK3 inhibitor VI [Ligand Id: 5995] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL323994
  • Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
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  • Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
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  • leucine rich repeat kinase 2 in Human [GtoPdb: 2059] [UniProtKB: Q5S007]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL Inhibition of JAK2 B 6.22 pIC50 600 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 5633-5638 [PMID:16934457]
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
ChEMBL Inhibition of JAK3 B 7.42 pIC50 38 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 5633-5638 [PMID:16934457]
ChEMBL Inhibitory activity against Janus Kinase 3 protein tyrosine kinase. B 7.57 pIC50 27 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 3105-3110 [PMID:12941344]
leucine rich repeat kinase 2 in Human [GtoPdb: 2059] [UniProtKB: Q5S007]
GtoPdb - - 7.66 pIC50 22 nM IC50

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]