ChEMBL ligand: CHEMBL323994
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] There should be some charts here, you may need to enable JavaScript!
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] There should be some charts here, you may need to enable JavaScript!
leucine rich repeat kinase 2 in Human [GtoPdb: 2059] [UniProtKB: Q5S007] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL	Inhibition of JAK2	B	6.22	pIC50	600	nM	IC50	Bioorg. Med. Chem. Lett. (2006) 16: 5633-5638 [PMID:16934457]
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
ChEMBL	Inhibition of JAK3	B	7.42	pIC50	38	nM	IC50	Bioorg. Med. Chem. Lett. (2006) 16: 5633-5638 [PMID:16934457]
ChEMBL	Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.	B	7.57	pIC50	27	nM	IC50	Bioorg. Med. Chem. Lett. (2003) 13: 3105-3110 [PMID:12941344]
leucine rich repeat kinase 2 in Human [GtoPdb: 2059] [UniProtKB: Q5S007]
GtoPdb	-	-	7.66	pIC50	22	nM	IC50

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]