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ChEMBL ligand: CHEMBL323994 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
ChEMBL | Inhibition of JAK2 | B | 6.22 | pIC50 | 600 | nM | IC50 | Bioorg. Med. Chem. Lett. (2006) 16: 5633-5638 [PMID:16934457] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
ChEMBL | Inhibition of JAK3 | B | 7.42 | pIC50 | 38 | nM | IC50 | Bioorg. Med. Chem. Lett. (2006) 16: 5633-5638 [PMID:16934457] |
ChEMBL | Inhibitory activity against Janus Kinase 3 protein tyrosine kinase. | B | 7.57 | pIC50 | 27 | nM | IC50 | Bioorg. Med. Chem. Lett. (2003) 13: 3105-3110 [PMID:12941344] |
leucine rich repeat kinase 2 in Human [GtoPdb: 2059] [UniProtKB: Q5S007] | ||||||||
GtoPdb | - | - | 7.66 | pIC50 | 22 | nM | IC50 |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]