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ChEMBL ligand: CHEMBL210618 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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protein kinase AMP-activated non-catalytic subunit beta 2/protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated catalytic subunit alpha 1/protein kinase AMP-activated non-catalytic subunit gamma 3/protein kinase AMP-activated non-catalytic subunit gamma 2/protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, AMPK in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2096907] [GtoPdb: 1544, 1545, 1542, 1541, 1547, 1546, 1543] [UniProtKB: O43741, P54619, P54646, Q13131, Q9UGI9, Q9UGJ0, Q9Y478] | ||||||||
ChEMBL | Inhibition of AMPK | B | 5.01 | pKi | >9800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566] | ||||||||
ChEMBL | Inhibition of CaMK4 | B | 5.07 | pKi | >8600 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] | ||||||||
ChEMBL | Inhibition of CK1delta | B | 5.11 | pKi | >7800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] | ||||||||
ChEMBL | Inhibition of CK2 | B | 5.24 | pKi | >5800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
ChEMBL | Inhibition of JNK1-mediated ATF2 phosphorylation | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ChEMBL | Inhibition of human JNK1 | B | 8.7 | pKi | 2 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
GtoPdb | - | - | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2006) 49: 3563-80 [PMID:16759099] |
ChEMBL | Inhibition of JNK1-mediated ATF2 phosphorylation | B | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ChEMBL | Inhibition of JNK1 | B | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2006) 49: 4455-4458 [PMID:16854050] |
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] | ||||||||
ChEMBL | Inhibition of human JNK2 | B | 8.4 | pKi | 4 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
GtoPdb | - | - | 8.4 | pKi | 4 | nM | Ki | J Med Chem (2006) 49: 3563-80 [PMID:16759099] |
ChEMBL | Inhibition of JNK2-mediated ATF2 phosphorylation | B | 6.8 | pIC50 | 160 | nM | IC50 | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] | ||||||||
GtoPdb | - | - | 7.28 | pKi | 52 | nM | Ki | J Med Chem (2006) 49: 3563-80 [PMID:16759099] |
ChEMBL | Inhibition of JNK3-mediated ATF2 phosphorylation | B | 7.28 | pKi | 52 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ChEMBL | Inhibition of human JNK3 | B | 7.28 | pKi | 52 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Inhibition of human JNK3 using ATF2 as substrate by [gamma-33P]-ATP assay | B | 6.11 | pIC50 | 770 | nM | IC50 | Eur J Med Chem (2019) 163: 453-480 [PMID:30530196] |
ChEMBL | Inhibition of human JNK3 using ATF2 as substrate by [gamma-33P]-ATP assay | B | 6.59 | pIC50 | 257 | nM | IC50 | Eur J Med Chem (2019) 161: 456-467 [PMID:30384048] |
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
ChEMBL | Inhibition of CDC2 | B | 5.05 | pKi | >8900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of CDK2 | B | 6.09 | pKi | 820 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535] | ||||||||
ChEMBL | Inhibition of CDK5 | B | 5.03 | pKi | >9300 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
death associated protein kinase 3/Death-associated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293] | ||||||||
ChEMBL | Inhibition of ZipK | B | 5.85 | pKi | >1400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] | ||||||||
ChEMBL | Inhibition of Dyrk1A | B | 5.16 | pKi | >6900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibition of EGFR | B | 5.74 | pKi | >1800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607] | ||||||||
ChEMBL | Inhibition of FGFR3 | B | 5.72 | pKi | >1900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] | ||||||||
ChEMBL | Inhibition of GSK3alpha | B | 5.05 | pKi | >8900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3-beta | B | 5.15 | pKi | >7100 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Inhibition of cMet | B | 5.54 | pKi | >2900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111] | ||||||||
ChEMBL | Inhibition of IKKalpha | B | 5.82 | pKi | >1500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
ChEMBL | Inhibition of IKK-beta | B | 5.49 | pKi | >3200 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibition of InsulinR | B | 5.28 | pKi | >5200 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3] | ||||||||
ChEMBL | Inhibition of IRAK4 | B | 5 | pKi | >9900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667] | ||||||||
ChEMBL | Inhibition of Limk1 | B | 5.02 | pKi | >9600 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333] | ||||||||
ChEMBL | Inhibition of CSF1R | B | 5.6 | pKi | >2500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
ChEMBL | Inhibition of MAPKAPK2 | B | 5.08 | pKi | >8400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
ChEMBL | Inhibition of MK3 | B | 5.04 | pKi | >9200 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of ERK2 | B | 5.33 | pKi | 4700 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
mitogen-activated protein kinase 13/MAP kinase p38 delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2939] [GtoPdb: 1502] [UniProtKB: O15264] | ||||||||
ChEMBL | Inhibition of p38delta | B | 5.16 | pKi | >6900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
mitogen-activated protein kinase 12/MAP kinase p38 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4674] [GtoPdb: 1501] [UniProtKB: P53778] | ||||||||
ChEMBL | Inhibition of p38-gamma | B | 5.12 | pKi | >7500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
microtubule affinity regulating kinase 2/MAP/microtubule affinity-regulating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831] [GtoPdb: 2098] [UniProtKB: Q7KZI7] | ||||||||
ChEMBL | Inhibition of EMK | B | 5.12 | pKi | >7500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
ChEMBL | Inhibition of TrkA | B | 5.6 | pKi | >2500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620] | ||||||||
ChEMBL | Inhibition of TrkB | B | 5.35 | pKi | >4500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
ChEMBL | Inhibition of PKCdelta | B | 5.05 | pKi | >8900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
protein kinase C eta/Protein kinase C eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723] | ||||||||
ChEMBL | Inhibition of PKCeta | B | 5.08 | pKi | >8300 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118] | ||||||||
ChEMBL | Inhibition of PDK1 | B | 5.42 | pKi | >3800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] | ||||||||
ChEMBL | Inhibition of ErbB2 | B | 5.85 | pKi | >1400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] | ||||||||
ChEMBL | Inhibition of ROCK1 | B | 5.04 | pKi | >9100 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] | ||||||||
ChEMBL | Inhibition of ROCK2 | B | 5.12 | pKi | >7500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812] | ||||||||
ChEMBL | Inhibition of RSK2 | B | 5.13 | pKi | >7400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ribosomal protein S6 kinase B1/ribosomal protein S6 kinase B2/Ribosomal protein S6 kinase (P70S6K) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111330] [GtoPdb: 1525, 1526] [UniProtKB: P23443, Q9UBS0] | ||||||||
ChEMBL | Inhibition of P70S6K | B | 5.47 | pKi | 3400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
ChEMBL | Inhibition of AKT1 | B | 5.09 | pKi | >8200 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751] | ||||||||
ChEMBL | Inhibition of AKT2 | B | 5.08 | pKi | >8400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243] | ||||||||
ChEMBL | Inhibition of AKT3 | B | 5.02 | pKi | >9500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
ChEMBL | Inhibition of Aurora1 | B | 5.16 | pKi | >6900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] | ||||||||
ChEMBL | Inhibition of Aurora2 | B | 5.17 | pKi | >6700 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
ChEMBL | Inhibition of CHK1 | B | 5.06 | pKi | >8800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017] | ||||||||
ChEMBL | Inhibition of CHK2 | B | 5.02 | pKi | >9500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448] | ||||||||
ChEMBL | Inhibition of CTAK1 | B | 5.17 | pKi | >6700 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6] | ||||||||
ChEMBL | Inhibition of Pkd2 | B | 5.28 | pKi | 5300 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ChEMBL | Inhibition of Pkd2 | B | 5.28 | pKi | 5300 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188] | ||||||||
ChEMBL | Inhibition of Mst2 | B | 5.06 | pKi | >8800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955] | ||||||||
ChEMBL | Inhibition of Nek2 | B | 6.04 | pKi | >920 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153] | ||||||||
ChEMBL | Inhibition of PAK1 | B | 5.01 | pKi | >9700 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013] | ||||||||
ChEMBL | Inhibition of PAK4 | B | 5.26 | pKi | >5500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
ChEMBL | Inhibition of Pim1 | B | 5.04 | pKi | >9200 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9] | ||||||||
ChEMBL | Inhibition of Pim2 | B | 5.85 | pKi | >1400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
ChEMBL | Inhibition of Plk1 | B | 5.05 | pKi | >8900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4] | ||||||||
ChEMBL | Inhibition of Plk3 | B | 5.1 | pKi | >8000 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
serum/glucocorticoid regulated kinase 1/Serine/threonine-protein kinase Sgk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2343] [GtoPdb: 1534] [UniProtKB: O00141] | ||||||||
ChEMBL | Inhibition of SGK | B | 5.03 | pKi | >9400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
ChEMBL | Inhibition of cKit | B | 5.92 | pKi | >1200 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912] | ||||||||
ChEMBL | Inhibition of CDC42 | B | 5.02 | pKi | >9500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
ChEMBL | Inhibition of Abl | B | 6.15 | pKi | >710 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451] | ||||||||
ChEMBL | Inhibition of Blk | B | 5.82 | pKi | >1500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
ChEMBL | Inhibition of Fyn | B | 6.09 | pKi | >810 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881] | ||||||||
ChEMBL | Inhibition of ITK | B | 5.42 | pKi | >3800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
ChEMBL | Inhibition of JAK2 | B | 5.82 | pKi | >1500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
ChEMBL | Inhibition of JAK3 | B | 5.77 | pKi | >1700 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of Lck | B | 5.57 | pKi | >2700 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] | ||||||||
ChEMBL | Inhibition of Lyn | B | 5.77 | pKi | >1700 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
ChEMBL | Inhibition of Flt3 | B | 5.6 | pKi | >2500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
ChEMBL | Inhibition of Src | B | 5.72 | pKi | >1900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
ChEMBL | Inhibition of Tyk2 | B | 5.72 | pKi | >1900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948] | ||||||||
ChEMBL | Inhibition of Flt1 | B | 6.36 | pKi | >440 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
ChEMBL | Inhibition of Kdr | B | 5.09 | pKi | >8200 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916] | ||||||||
ChEMBL | Inhibition of Flt4 | B | 5.15 | pKi | >7100 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]