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ChEMBL ligand: CHEMBL210618 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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protein kinase AMP-activated non-catalytic subunit beta 2/protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated catalytic subunit alpha 1/protein kinase AMP-activated non-catalytic subunit gamma 3/protein kinase AMP-activated non-catalytic subunit gamma 2/protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, AMPK in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2096907] [GtoPdb: 1544, 1545, 1542, 1541, 1547, 1546, 1543] [UniProtKB: O43741, P54619, P54646, Q13131, Q9UGI9, Q9UGJ0, Q9Y478] | ||||||||
ChEMBL | Inhibition of AMPK | B | 5.01 | pKi | >9800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566] | ||||||||
ChEMBL | Inhibition of CaMK4 | B | 5.07 | pKi | >8600 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] | ||||||||
ChEMBL | Inhibition of CK1delta | B | 5.11 | pKi | >7800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] | ||||||||
ChEMBL | Inhibition of CK2 | B | 5.24 | pKi | >5800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
ChEMBL | Inhibition of JNK1-mediated ATF2 phosphorylation | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ChEMBL | Inhibition of human JNK1 | B | 8.7 | pKi | 2 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
GtoPdb | - | - | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2006) 49: 3563-80 [PMID:16759099] |
ChEMBL | Inhibition of JNK1-mediated ATF2 phosphorylation | B | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ChEMBL | Inhibition of JNK1 | B | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2006) 49: 4455-4458 [PMID:16854050] |
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] | ||||||||
ChEMBL | Inhibition of human JNK2 | B | 8.4 | pKi | 4 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
GtoPdb | - | - | 8.4 | pKi | 4 | nM | Ki | J Med Chem (2006) 49: 3563-80 [PMID:16759099] |
ChEMBL | Inhibition of JNK2-mediated ATF2 phosphorylation | B | 6.8 | pIC50 | 160 | nM | IC50 | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] | ||||||||
GtoPdb | - | - | 7.28 | pKi | 52 | nM | Ki | J Med Chem (2006) 49: 3563-80 [PMID:16759099] |
ChEMBL | Inhibition of JNK3-mediated ATF2 phosphorylation | B | 7.28 | pKi | 52 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ChEMBL | Inhibition of human JNK3 | B | 7.28 | pKi | 52 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Inhibition of human JNK3 using ATF2 as substrate by [gamma-33P]-ATP assay | B | 6.11 | pIC50 | 770 | nM | IC50 | Eur J Med Chem (2019) 163: 453-480 [PMID:30530196] |
ChEMBL | Inhibition of human JNK3 using ATF2 as substrate by [gamma-33P]-ATP assay | B | 6.59 | pIC50 | 257 | nM | IC50 | Eur J Med Chem (2019) 161: 456-467 [PMID:30384048] |
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
ChEMBL | Inhibition of CDC2 | B | 5.05 | pKi | >8900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of CDK2 | B | 6.09 | pKi | 820 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535] | ||||||||
ChEMBL | Inhibition of CDK5 | B | 5.03 | pKi | >9300 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
death associated protein kinase 3/Death-associated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293] | ||||||||
ChEMBL | Inhibition of ZipK | B | 5.85 | pKi | >1400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] | ||||||||
ChEMBL | Inhibition of Dyrk1A | B | 5.16 | pKi | >6900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibition of EGFR | B | 5.74 | pKi | >1800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607] | ||||||||
ChEMBL | Inhibition of FGFR3 | B | 5.72 | pKi | >1900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] | ||||||||
ChEMBL | Inhibition of GSK3alpha | B | 5.05 | pKi | >8900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3-beta | B | 5.15 | pKi | >7100 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Inhibition of cMet | B | 5.54 | pKi | >2900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111] | ||||||||
ChEMBL | Inhibition of IKKalpha | B | 5.82 | pKi | >1500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
ChEMBL | Inhibition of IKK-beta | B | 5.49 | pKi | >3200 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibition of InsulinR | B | 5.28 | pKi | >5200 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3] | ||||||||
ChEMBL | Inhibition of IRAK4 | B | 5 | pKi | >9900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667] | ||||||||
ChEMBL | Inhibition of Limk1 | B | 5.02 | pKi | >9600 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333] | ||||||||
ChEMBL | Inhibition of CSF1R | B | 5.6 | pKi | >2500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
ChEMBL | Inhibition of MAPKAPK2 | B | 5.08 | pKi | >8400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
ChEMBL | Inhibition of MK3 | B | 5.04 | pKi | >9200 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of ERK2 | B | 5.33 | pKi | 4700 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
mitogen-activated protein kinase 13/MAP kinase p38 delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2939] [GtoPdb: 1502] [UniProtKB: O15264] | ||||||||
ChEMBL | Inhibition of p38delta | B | 5.16 | pKi | >6900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
mitogen-activated protein kinase 12/MAP kinase p38 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4674] [GtoPdb: 1501] [UniProtKB: P53778] | ||||||||
ChEMBL | Inhibition of p38-gamma | B | 5.12 | pKi | >7500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
microtubule affinity regulating kinase 2/MAP/microtubule affinity-regulating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831] [GtoPdb: 2098] [UniProtKB: Q7KZI7] | ||||||||
ChEMBL | Inhibition of EMK | B | 5.12 | pKi | >7500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
ChEMBL | Inhibition of TrkA | B | 5.6 | pKi | >2500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620] | ||||||||
ChEMBL | Inhibition of TrkB | B | 5.35 | pKi | >4500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
ChEMBL | Inhibition of PKCdelta | B | 5.05 | pKi | >8900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
protein kinase C eta/Protein kinase C eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723] | ||||||||
ChEMBL | Inhibition of PKCeta | B | 5.08 | pKi | >8300 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118] | ||||||||
ChEMBL | Inhibition of PDK1 | B | 5.42 | pKi | >3800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] | ||||||||
ChEMBL | Inhibition of ErbB2 | B | 5.85 | pKi | >1400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] | ||||||||
ChEMBL | Inhibition of ROCK1 | B | 5.04 | pKi | >9100 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] | ||||||||
ChEMBL | Inhibition of ROCK2 | B | 5.12 | pKi | >7500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812] | ||||||||
ChEMBL | Inhibition of RSK2 | B | 5.13 | pKi | >7400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ribosomal protein S6 kinase B1/ribosomal protein S6 kinase B2/Ribosomal protein S6 kinase (P70S6K) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111330] [GtoPdb: 1525, 1526] [UniProtKB: P23443, Q9UBS0] | ||||||||
ChEMBL | Inhibition of P70S6K | B | 5.47 | pKi | 3400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
ChEMBL | Inhibition of AKT1 | B | 5.09 | pKi | >8200 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751] | ||||||||
ChEMBL | Inhibition of AKT2 | B | 5.08 | pKi | >8400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243] | ||||||||
ChEMBL | Inhibition of AKT3 | B | 5.02 | pKi | >9500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
ChEMBL | Inhibition of Aurora1 | B | 5.16 | pKi | >6900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] | ||||||||
ChEMBL | Inhibition of Aurora2 | B | 5.17 | pKi | >6700 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
ChEMBL | Inhibition of CHK1 | B | 5.06 | pKi | >8800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017] | ||||||||
ChEMBL | Inhibition of CHK2 | B | 5.02 | pKi | >9500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448] | ||||||||
ChEMBL | Inhibition of CTAK1 | B | 5.17 | pKi | >6700 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6] | ||||||||
ChEMBL | Inhibition of Pkd2 | B | 5.28 | pKi | 5300 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ChEMBL | Inhibition of Pkd2 | B | 5.28 | pKi | 5300 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188] | ||||||||
ChEMBL | Inhibition of Mst2 | B | 5.06 | pKi | >8800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955] | ||||||||
ChEMBL | Inhibition of Nek2 | B | 6.04 | pKi | >920 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153] | ||||||||
ChEMBL | Inhibition of PAK1 | B | 5.01 | pKi | >9700 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013] | ||||||||
ChEMBL | Inhibition of PAK4 | B | 5.26 | pKi | >5500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
ChEMBL | Inhibition of Pim1 | B | 5.04 | pKi | >9200 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9] | ||||||||
ChEMBL | Inhibition of Pim2 | B | 5.85 | pKi | >1400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
ChEMBL | Inhibition of Plk1 | B | 5.05 | pKi | >8900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4] | ||||||||
ChEMBL | Inhibition of Plk3 | B | 5.1 | pKi | >8000 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
serum/glucocorticoid regulated kinase 1/Serine/threonine-protein kinase Sgk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2343] [GtoPdb: 1534] [UniProtKB: O00141] | ||||||||
ChEMBL | Inhibition of SGK | B | 5.03 | pKi | >9400 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
ChEMBL | Inhibition of cKit | B | 5.92 | pKi | >1200 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912] | ||||||||
ChEMBL | Inhibition of CDC42 | B | 5.02 | pKi | >9500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
ChEMBL | Inhibition of Abl | B | 6.15 | pKi | >710 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451] | ||||||||
ChEMBL | Inhibition of Blk | B | 5.82 | pKi | >1500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
ChEMBL | Inhibition of Fyn | B | 6.09 | pKi | >810 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881] | ||||||||
ChEMBL | Inhibition of ITK | B | 5.42 | pKi | >3800 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
ChEMBL | Inhibition of JAK2 | B | 5.82 | pKi | >1500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
ChEMBL | Inhibition of JAK3 | B | 5.77 | pKi | >1700 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of Lck | B | 5.57 | pKi | >2700 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] | ||||||||
ChEMBL | Inhibition of Lyn | B | 5.77 | pKi | >1700 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
ChEMBL | Inhibition of Flt3 | B | 5.6 | pKi | >2500 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
ChEMBL | Inhibition of Src | B | 5.72 | pKi | >1900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
ChEMBL | Inhibition of Tyk2 | B | 5.72 | pKi | >1900 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948] | ||||||||
ChEMBL | Inhibition of Flt1 | B | 6.36 | pKi | >440 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
ChEMBL | Inhibition of Kdr | B | 5.09 | pKi | >8200 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916] | ||||||||
ChEMBL | Inhibition of Flt4 | B | 5.15 | pKi | >7100 | nM | Ki | J Med Chem (2006) 49: 3563-3580 [PMID:16759099] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]