PDGF receptor tyrosine kinase inhibitor II [Ligand Id: 6018] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL266325
  • platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor in Human [ChEMBL: CHEMBL2095189] [GtoPdb: 18041803] [UniProtKB: P09619P16234]
  • platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha in Mouse [GtoPdb: 18041803] [UniProtKB: P05622P26618]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095189] [GtoPdb: 18041803] [UniProtKB: P09619P16234]
ChEMBL Antitumor activity measured by the inhibition of platelet-derived growth factor receptor autophosphorylation in intact Swiss 3T3 cells B 5.96 pIC50 1100 nM IC50 J. Med. Chem. (2002) 45: 1002-1018 [PMID:11855980]
platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha in Mouse [GtoPdb: 18041803] [UniProtKB: P05622P26618]
GtoPdb Inhibition of PDGFR in intact Swiss 3T3 fibroblasts - 5.96 pIC50 1100 nM IC50 J. Med. Chem. (2002) 45: 1002-18 [PMID:11855980]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]