PDGF receptor tyrosine kinase inhibitor III [Ligand Id: 6019] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL102346 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Inhibition of Epidermal growth factor receptor | B | 4.52 | pIC50 | >30000 | nM | IC50 | J Med Chem (2002) 45: 3057-3066 [PMID:12086491] |
| platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095189] [GtoPdb: 1804, 1803] [UniProtKB: P09619, P16234] | ||||||||
| ChEMBL | Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two site ELISA | B | 7.1 | pIC50 | 80 | nM | IC50 | J Med Chem (2002) 45: 4513-4523 [PMID:12238930] |
| GtoPdb | - | - | 7.1 | pIC50 | 80 | nM | IC50 | J Med Chem (2003) 46: 4910-25 [PMID:14584942] |
| platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] | ||||||||
| ChEMBL | Inhibition of Platelet-derived growth factor receptor alpha | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (2002) 45: 3057-3066 [PMID:12086491] |
| platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
| ChEMBL | Inhibition of Platelet-derived growth factor receptor beta | B | 6.89 | pIC50 | 130 | nM | IC50 | J Med Chem (2002) 45: 3057-3066 [PMID:12086491] |
| ChEMBL | Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent assay (ELISA) | B | 7.1 | pIC50 | 80 | nM | IC50 | J Med Chem (2003) 46: 4910-4925 [PMID:14584942] |
| ChEMBL | Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells | F | 7.1 | pIC50 | >80 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3001-3004 [PMID:12941321] |
| ChEMBL | Inhibition of Platelet-derived growth factor receptor beta phosphorylation | B | 7.1 | pIC50 | 80 | nM | IC50 | J Med Chem (2002) 45: 3057-3066 [PMID:12086491] |
| GtoPdb | - | - | 7.1 | pIC50 | 80 | nM | IC50 | J Med Chem (2003) 46: 4910-25 [PMID:14584942] |
| KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
| ChEMBL | Inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (2002) 45: 3057-3066 [PMID:12086491] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Inhibition of Flt3 kinase | B | 6.64 | pIC50 | 230 | nM | IC50 | J Med Chem (2002) 45: 3057-3066 [PMID:12086491] |
| SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| ChEMBL | Inhibition of Src protein tyrosine kinase | B | 4.52 | pIC50 | >30000 | nM | IC50 | J Med Chem (2002) 45: 3057-3066 [PMID:12086491] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
