PKR inhibitor [Ligand Id: 6026] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL235641
  • NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98]
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  • NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
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  • eukaryotic translation initiation factor 2 alpha kinase 2 in Human [GtoPdb: 2016] [UniProtKB: P19525]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98]
ChEMBL Inhibition of human NEK6 using casein as substrate by [gamma-33P]-ATP assay B 4.22 pIC50 59800 nM IC50 Eur J Med Chem (2019) 161: 456-467 [PMID:30384048]
NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
ChEMBL Inhibition of human NEK7 using casein as substrate by [gamma-33P]-ATP assay B 5.14 pIC50 7280 nM IC50 Eur J Med Chem (2019) 161: 456-467 [PMID:30384048]
eukaryotic translation initiation factor 2 alpha kinase 2 in Human [GtoPdb: 2016] [UniProtKB: P19525]
GtoPdb - - 6.68 pIC50 210 nM IC50 Biochem Biophys Res Commun (2003) 308: 50-7 [PMID:12890478]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]