Ro-32-0432 [Ligand Id: 6034] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL26501 (Ro-32-0432)
  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
  • This target only has 0 pki data point
  • 0
1 CHEMBL26501_lig_chart_1 Glycogen synthase kinase-3 beta Human
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  • phosphorylase kinase catalytic subunit gamma 2/phosphorylase kinase catalytic subunit gamma 1/Phosphorylase kinase in Human [ChEMBL: CHEMBL2111324] [GtoPdb: 21472145] [UniProtKB: P15735P46019P46020Q16816Q93100]
  • This target only has 0 pki data point
  • 0
2 CHEMBL26501_lig_chart_2 Phosphorylase kinase Human
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  • protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
  • protein kinase C alpha in Bovine [GtoPdb: 1482]
  • protein kinase C alpha/Protein kinase C alpha in Rat [ChEMBL: CHEMBL2855] [GtoPdb: 1482] [UniProtKB: P05696]
  • This target only has 0 pki data point
  • 0
3 CHEMBL26501_lig_chart_3 Protein kinase C alpha HumanBovineRat
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  • protein kinase C beta in Bovine [GtoPdb: 1483]
  • protein kinase C beta/Protein kinase C beta in Rat [ChEMBL: CHEMBL3020] [GtoPdb: 1483] [UniProtKB: P68403]
  • This target only has 0 pki data point
  • 0
4 CHEMBL26501_lig_chart_4 protein kinase C beta BovineRat
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  • protein kinase C epsilon in Mouse [GtoPdb: 1486] [UniProtKB: P16054]
  • protein kinase C epsilon/Protein kinase C epsilon in Rat [ChEMBL: CHEMBL3424] [GtoPdb: 1486] [UniProtKB: P09216]
  • This target only has 0 pki data point
  • 0
5 CHEMBL26501_lig_chart_5 protein kinase C epsilon MouseRat
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  • protein kinase C gamma in Bovine [GtoPdb: 1484]
  • protein kinase C gamma/Protein kinase C gamma in Rat [ChEMBL: CHEMBL3604] [GtoPdb: 1484] [UniProtKB: P63319]
  • This target only has 0 pki data point
  • 0
6 CHEMBL26501_lig_chart_6 protein kinase C gamma BovineRat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counting B 7.7 pIC50 20 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 1693-1696 [PMID:20138512]
phosphorylase kinase catalytic subunit gamma 2/phosphorylase kinase catalytic subunit gamma 1/Phosphorylase kinase in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2111324] [GtoPdb: 21472145] [UniProtKB: P15735P46019P46020Q16816Q93100]
ChEMBL Inhibition of phosphorylase kinase (PhK) B 4.81 pIC50 15625 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 1303-1308
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL Inhibition of PKCalpha B 7.66 pIC50 22 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 1693-1696 [PMID:20138512]
protein kinase C alpha in Bovine [GtoPdb: 1482]
GtoPdb - - 8.05 pIC50 9 nM IC50 J Pharmacol Exp Ther (1994) 268: 922-9 [PMID:8114006];
Biochem J (1993) 294 ( Pt 2): 335-7 [PMID:8373348]
protein kinase C alpha/Protein kinase C alpha in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2855] [GtoPdb: 1482] [UniProtKB: P05696]
ChEMBL Inhibition of Protein kinase C alpha B 8.06 pIC50 8.8 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 1303-1308
protein kinase C beta in Bovine [GtoPdb: 1483]
GtoPdb - - 7.52 pIC50 30 nM IC50 J Pharmacol Exp Ther (1994) 268: 922-9 [PMID:8114006];
Biochem J (1993) 294 ( Pt 2): 335-7 [PMID:8373348]
protein kinase C beta/Protein kinase C beta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3020] [GtoPdb: 1483] [UniProtKB: P68403]
ChEMBL Inhibition of Protein kinase C beta B 7.52 pIC50 30.5 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 1303-1308
ChEMBL Inhibition of Protein kinase C beta 1 B 7.55 pIC50 28 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 1303-1308
protein kinase C epsilon in Mouse [GtoPdb: 1486] [UniProtKB: P16054]
GtoPdb - - 6.97 pIC50 108 nM IC50 J Pharmacol Exp Ther (1994) 268: 922-9 [PMID:8114006];
Biochem J (1993) 294 ( Pt 2): 335-7 [PMID:8373348]
protein kinase C epsilon/Protein kinase C epsilon in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3424] [GtoPdb: 1486] [UniProtKB: P09216]
ChEMBL Inhibition of Protein kinase C epsilon B 6.98 pIC50 105 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 1303-1308
protein kinase C gamma in Bovine [GtoPdb: 1484]
GtoPdb - - 7.44 pIC50 36.5 nM IC50 J Pharmacol Exp Ther (1994) 268: 922-9 [PMID:8114006];
Biochem J (1993) 294 ( Pt 2): 335-7 [PMID:8373348]
protein kinase C gamma/Protein kinase C gamma in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3604] [GtoPdb: 1484] [UniProtKB: P63319]
ChEMBL Inhibition of Protein kinase C gamma (PKC) B 7.44 pIC50 36.5 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 1303-1308

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]