Ro-32-0432 [Ligand Id: 6034] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL26501 (Ro-32-0432)
  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
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  • protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
  • protein kinase C alpha in Bovine [GtoPdb: 1482]
  • protein kinase C alpha/Protein kinase C alpha in Rat [ChEMBL: CHEMBL2855] [GtoPdb: 1482] [UniProtKB: P05696]
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  • protein kinase C beta in Bovine [GtoPdb: 1483]
  • protein kinase C beta/Protein kinase C beta in Rat [ChEMBL: CHEMBL3020] [GtoPdb: 1483] [UniProtKB: P68403]
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  • protein kinase C epsilon in Mouse [GtoPdb: 1486] [UniProtKB: P16054]
  • protein kinase C epsilon/Protein kinase C epsilon in Rat [ChEMBL: CHEMBL3424] [GtoPdb: 1486] [UniProtKB: P09216]
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  • protein kinase C gamma in Bovine [GtoPdb: 1484]
  • protein kinase C gamma/Protein kinase C gamma in Rat [ChEMBL: CHEMBL3604] [GtoPdb: 1484] [UniProtKB: P63319]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counting B 7.7 pIC50 20 nM IC50 Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512]
phosphorylase kinase catalytic subunit gamma 2/phosphorylase kinase catalytic subunit gamma 1/Phosphorylase kinase in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2111324] [GtoPdb: 2147, 2145] [UniProtKB: P15735, P46019, P46020, Q16816, Q93100]
ChEMBL Inhibition of phosphorylase kinase (PhK) B 4.81 pIC50 15625 nM IC50 Bioorg Med Chem Lett (1994) 4: 1303-1308
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL Inhibition of PKCalpha B 7.66 pIC50 22 nM IC50 Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512]
protein kinase C alpha in Bovine [GtoPdb: 1482]
GtoPdb - - 8.05 pIC50 9 nM IC50 J Pharmacol Exp Ther (1994) 268: 922-9 [PMID:8114006];
Biochem J (1993) 294 ( Pt 2): 335-7 [PMID:8373348]
protein kinase C alpha/Protein kinase C alpha in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2855] [GtoPdb: 1482] [UniProtKB: P05696]
ChEMBL Inhibition of Protein kinase C alpha B 8.06 pIC50 8.8 nM IC50 Bioorg Med Chem Lett (1994) 4: 1303-1308
protein kinase C beta in Bovine [GtoPdb: 1483]
GtoPdb - - 7.52 pIC50 30 nM IC50 J Pharmacol Exp Ther (1994) 268: 922-9 [PMID:8114006];
Biochem J (1993) 294 ( Pt 2): 335-7 [PMID:8373348]
protein kinase C beta/Protein kinase C beta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3020] [GtoPdb: 1483] [UniProtKB: P68403]
ChEMBL Inhibition of Protein kinase C beta B 7.52 pIC50 30.5 nM IC50 Bioorg Med Chem Lett (1994) 4: 1303-1308
ChEMBL Inhibition of Protein kinase C beta 1 B 7.55 pIC50 28 nM IC50 Bioorg Med Chem Lett (1994) 4: 1303-1308
protein kinase C epsilon in Mouse [GtoPdb: 1486] [UniProtKB: P16054]
GtoPdb - - 6.97 pIC50 108 nM IC50 J Pharmacol Exp Ther (1994) 268: 922-9 [PMID:8114006];
Biochem J (1993) 294 ( Pt 2): 335-7 [PMID:8373348]
protein kinase C epsilon/Protein kinase C epsilon in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3424] [GtoPdb: 1486] [UniProtKB: P09216]
ChEMBL Inhibition of Protein kinase C epsilon B 6.98 pIC50 105 nM IC50 Bioorg Med Chem Lett (1994) 4: 1303-1308
protein kinase C gamma in Bovine [GtoPdb: 1484]
GtoPdb - - 7.44 pIC50 36.5 nM IC50 J Pharmacol Exp Ther (1994) 268: 922-9 [PMID:8114006];
Biochem J (1993) 294 ( Pt 2): 335-7 [PMID:8373348]
protein kinase C gamma/Protein kinase C gamma in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3604] [GtoPdb: 1484] [UniProtKB: P63319]
ChEMBL Inhibition of Protein kinase C gamma (PKC) B 7.44 pIC50 36.5 nM IC50 Bioorg Med Chem Lett (1994) 4: 1303-1308

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]