SU11652 [Ligand Id: 6043] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL13485 (SU-11652)
  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
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  • maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680]
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  • platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha in Human [GtoPdb: 18041803] [UniProtKB: P09619P16234]
  • platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor in Mouse [ChEMBL: CHEMBL2096980] [GtoPdb: 18041803] [UniProtKB: P05622P26618]
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  • platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
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  • NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
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  • KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721]
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  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of epidermal growth factor receptor (EGF-R) B 4.7 pIC50 >20000 nM IC50 J. Med. Chem. (2003) 46: 1116-1119 [PMID:12646019]
ChEMBL Inhibition of EGFR B 4.7 pIC50 >20000 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL Inhibition of EGFR B 5.52 pIC50 3000 nM IC50 J. Biol. Chem. (2007) 282: 6833-6842 [PMID:17197699]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL Inhibition of Fibroblast growth factor receptor 1 B 6.77 pIC50 170 nM IC50 J. Med. Chem. (2003) 46: 1116-1119 [PMID:12646019]
ChEMBL Inhibition of FGFR1 B 6.77 pIC50 170 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
GtoPdb - - 6.77 pIC50 170 nM IC50 J. Med. Chem. (2003) 46: 1116-9 [PMID:12646019]
maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680]
ChEMBL Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as substrate measured after 30 mins in presence of [gamma32P]ATP by liquid scintillation counting method B 6.12 pIC50 760 nM IC50 Bioorg Med Chem (2017) 25: 2609-2616 [PMID:28351607]
platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha in Human [GtoPdb: 18041803] [UniProtKB: P09619P16234]
GtoPdb - - 8.52 pIC50 3 nM IC50 J. Med. Chem. (2003) 46: 1116-9 [PMID:12646019]
platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor in Mouse (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096980] [GtoPdb: 18041803] [UniProtKB: P05622P26618]
ChEMBL Inhibition of Platelet-derived growth factor induced 3T3 cell proliferation F 7 pIC50 100 nM IC50 J. Med. Chem. (2003) 46: 1116-1119 [PMID:12646019]
ChEMBL Inhibition of PDGF-induced BrdU incorporation in 3T3 cells F 7.15 pIC50 <70 nM IC50 J. Med. Chem. (2003) 46: 1116-1119 [PMID:12646019]
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
ChEMBL Inhibition of PDGFRbeta B 5.52 pIC50 3000 nM IC50 J. Biol. Chem. (2007) 282: 6833-6842 [PMID:17197699]
GtoPdb - - 8.52 pIC50 3 nM IC50 J. Med. Chem. (2003) 46: 1116-9 [PMID:12646019]
ChEMBL Inhibition of Platelet-derived growth factor receptor beta (PDGF-Rbeta) B 8.52 pIC50 3 nM IC50 J. Med. Chem. (2003) 46: 1116-1119 [PMID:12646019]
ChEMBL Inhibition of PDGFRbeta B 8.52 pIC50 3 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
ChEMBL Inhibition of human recombinant Nek2 T175A mutant by coupled pyruvate kinase/lactate dehydrogenase assay B 5.1 pIC50 8000 nM IC50 J. Biol. Chem. (2007) 282: 6833-6842 [PMID:17197699]
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721]
GtoPdb - - 8 pIC50 10 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-8 [PMID:18077363]
ChEMBL Inhibition of c-kit B 8 pIC50 10 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL Inhibition of VEGFR2 B 5.52 pIC50 3000 nM IC50 J. Biol. Chem. (2007) 282: 6833-6842 [PMID:17197699]
ChEMBL Inhibition of Vascular endothelial growth factor receptor 2 B 7.57 pIC50 27 nM IC50 J. Med. Chem. (2003) 46: 1116-1119 [PMID:12646019]
ChEMBL Inhibition of VEGFR2 B 7.57 pIC50 27 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
GtoPdb - - 7.57 pIC50 27 nM IC50 J. Med. Chem. (2003) 46: 1116-9 [PMID:12646019]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]