Syk inhibitor III [Ligand Id: 6048] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL596380 (3,4-Methylenedioxyb-Nitrostyrene)
  • NLRP3/NACHT, LRR and PYD domains-containing protein 3 in Mouse [ChEMBL: CHEMBL3779755] [GtoPdb: 1770] [UniProtKB: Q8R4B8]
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  • SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931]
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  • spleen associated tyrosine kinase in Human [GtoPdb: 2230] [UniProtKB: P43405]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
NLRP3/NACHT, LRR and PYD domains-containing protein 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3779755] [GtoPdb: 1770] [UniProtKB: Q8R4B8]
ChEMBL Inhibition of NLRP3 in LPS stimulated mouse BMDM cells after 15 mins followed by addition of ATP by ELISA analysis B 5.7 pIC50 2000 nM IC50 J. Med. Chem. (2016) 59: 1691-1710 [PMID:26422006]
ChEMBL Inhibition of NLRP3 inflammasome activation in LPS-primed mouse bone marrow derived macrophages preincubated for 15 mins followed by addition of ATP and measured after 30 mins by ELISA method B 5.7 pIC50 2000 nM IC50 Eur J Med Chem (2020) 185: 111822-111822 [PMID:31699536]
SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931]
GtoPdb - - 4.56 pIC50 27300 nM IC50 Biochem Pharmacol (2007) 74: 601-11 [PMID:17601492]
spleen associated tyrosine kinase in Human [GtoPdb: 2230] [UniProtKB: P43405]
GtoPdb - - 5.55 pIC50 2800 nM IC50 Biochem Pharmacol (2007) 74: 601-11 [PMID:17601492]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]