VEGF receptor tyrosine kinase inhibitor II | Ligand Activity Charts

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VEGF receptor tyrosine kinase inhibitor II
Ligand Activity Charts

VEGF receptor tyrosine kinase inhibitor II [Ligand Id: 6056] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL101683
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] There should be some charts here, you may need to enable JavaScript!
Insulin-like growth factor I receptor in Human [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] There should be some charts here, you may need to enable JavaScript!
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
ChEMBL	Inhibition of Cyclin-dependent kinase 1	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Inhibition of Epidermal growth factor receptor	B	5.14	pIC50	7300	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313]
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL	Inhibition of Met proto-oncogene tyrosine kinase	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313]
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
ChEMBL	Inhibition of Insulin-like growth factor I receptor	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313]
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721]
ChEMBL	Inhibition of Proto-oncogene tyrosine-protein kinase Kit	B	6.62	pIC50	240	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Inhibition of c-Src tyrosine kinase	B	5.15	pIC50	7000	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313]
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
ChEMBL	Inhibition of vascular endothelial growth factor receptor 1	B	6.74	pIC50	180	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
GtoPdb	-	-	7.82	pKi	15	nM	Ki	Bioorg Med Chem Lett (2007) 17: 6003-8 [PMID:17869515]
ChEMBL	Inhibition of phosphorylated-Kdr after 30 mins	B	7.82	pKi	15	nM	Ki	Bioorg Med Chem Lett (2007) 17: 6003-6008 [PMID:17869515]
ChEMBL	Inhibition of Vascular endothelial growth factor receptor 2	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313]
ChEMBL	Inhibition of KDR by ELISA	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2939-2943 [PMID:18420406]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]