tivozanib [Ligand Id: 6058] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1289494 (ASP-4130, KIL8951, Kil-8951, Fotivda, Krn-951, KRN-951, AV-951, Tivozanib)
  • EPH receptor B2/Ephrin type-B receptor 2 in Human [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323]
  • This target only has 0 pki data point
  • 0
1 CHEMBL1289494_lig_chart_1 Ephrin type-B receptor 2 Human
There should be some charts here, you may need to enable JavaScript!
  • platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
  • This target only has 0 pki data point
  • 0
2 CHEMBL1289494_lig_chart_2 Platelet-derived growth factor receptor alpha Human
There should be some charts here, you may need to enable JavaScript!
  • fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
  • This target only has 0 pki data point
  • 0
3 CHEMBL1289494_lig_chart_3 Vascular endothelial growth factor receptor 1 Human
There should be some charts here, you may need to enable JavaScript!
  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
  • This target only has 0 pki data point
  • 0
4 CHEMBL1289494_lig_chart_4 Vascular endothelial growth factor receptor 2 Human
There should be some charts here, you may need to enable JavaScript!
  • fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916]
  • This target only has 0 pki data point
  • 0
5 CHEMBL1289494_lig_chart_5 Vascular endothelial growth factor receptor 3 Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323]
ChEMBL Inhibition of recombinant EphB2 (unknown origin) by cell-free assay B 7.76 pIC50 17.5 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 2425-2428 [PMID:25908516]
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
ChEMBL Inhibition of recombinant PDGFRalpha (unknown origin) by cell-free assay B 8.65 pIC50 2.26 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 2425-2428 [PMID:25908516]
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
ChEMBL Inhibition of recombinant VEGFR1 (unknown origin) by cell-free assay B 8.2 pIC50 6.26 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 2425-2428 [PMID:25908516]
ChEMBL Inhibition of VEGFR1 B 9.68 pIC50 0.21 nM IC50 J. Med. Chem. (2012) 55: 10797-10822 [PMID:23098265]
GtoPdb - - 9.68 pIC50 0.21 nM IC50 J Med Chem (2012) 55: 10797-822 [PMID:23098265]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL Inhibition of VEGFR2 (unknown origin) B 6.47 pIC50 340 nM IC50 Eur. J. Med. Chem. (2014) 76: 193-244 [PMID:24583357]
ChEMBL Inhibition of recombinant VEGFR2 (unknown origin) by cell-free assay B 8.67 pIC50 2.14 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 2425-2428 [PMID:25908516]
ChEMBL Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assay B 9.8 pIC50 0.16 nM IC50 Eur. J. Med. Chem. (2010) 45: 5420-5427 [PMID:20869793]
ChEMBL Inhibition of VEGFR2 B 9.8 pIC50 0.16 nM IC50 J. Med. Chem. (2012) 55: 10797-10822 [PMID:23098265]
GtoPdb - - 9.8 pIC50 0.16 nM IC50 J Med Chem (2012) 55: 10797-822 [PMID:23098265]
fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916]
ChEMBL Inhibition of recombinant VEGFR3 (unknown origin) by cell-free assay B 8.51 pIC50 3.11 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 2425-2428 [PMID:25908516]
ChEMBL Inhibition of VEGFR3 B 9.62 pIC50 0.24 nM IC50 J. Med. Chem. (2012) 55: 10797-10822 [PMID:23098265]
GtoPdb - - 9.62 pIC50 0.24 nM IC50 J Med Chem (2012) 55: 10797-822 [PMID:23098265]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]