ChEMBL ligand: CHEMBL205596 (Cholalic acid, Cholbam, Cholic acid, Cholic Acid, E1000, Kolbam, NSC-6135, Orphacol)
Farnesoid X receptor/Bile acid receptor FXR in Human [ChEMBL: CHEMBL2047] [GtoPdb: 603] [UniProtKB: Q96RI1] There should be some charts here, you may need to enable JavaScript!
GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6] GPBA receptor/G-protein coupled bile acid receptor 1 in Mouse [ChEMBL: CHEMBL1255150] [GtoPdb: 37] [UniProtKB: Q80SS6] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Farnesoid X receptor/Bile acid receptor FXR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2047] [GtoPdb: 603] [UniProtKB: Q96RI1]
ChEMBL	Agonist activity at FXR expressed in COS1 cells by cell-based bioluminescence assay	F	4	pEC50	>100000	nM	EC50	J. Med. Chem. (2009) 52: 7958-7961 [PMID:20014870]
ChEMBL	Agonist activity at GST-tagged FXR-LBD using biotinylated-SRC-1 peptide as substrate preincubated with compound for 30 mins measured after 4 hrs	F	4	pEC50	>100000	nM	EC50	ACS Med. Chem. Lett. (2012) 3: 273-277 [PMID:24900463]
ChEMBL	Agonist activity at GST-tagged FXR-LBD (unknown origin) assessed as biotin-labeled SRC-1 recruitment after 30 mins by Alpha Screen assay	B	4.35	pEC50	45000	nM	EC50	Eur J Med Chem (2018) 144: 349-358 [PMID:29275233]
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
ChEMBL	Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level	F	5.22	pIC50	6000	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 5718-5721 [PMID:20801037]
ChEMBL	Agonist activity at wild type TGR5 (unknown origin)	B	4.7	pEC50	19830	nM	EC50	ACS Med. Chem. Lett. (2013) 4: 1158-1162 [PMID:24900622]
ChEMBL	Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay	F	4.87	pEC50	13600	nM	EC50	J. Med. Chem. (2007) 50: 4265-4268 [PMID:17685603]
ChEMBL	Agonist activity at human TGR5 expressed in CHO cells by luciferase assay	F	4.87	pEC50	13600	nM	EC50	J. Med. Chem. (2008) 51: 1831-1841 [PMID:18307294]
ChEMBL	Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay	F	4.87	pEC50	13600	nM	EC50	J. Med. Chem. (2009) 52: 7958-7961 [PMID:20014870]
ChEMBL	Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis	F	4.87	pEC50	13600	nM	EC50	ACS Med. Chem. Lett. (2012) 3: 273-277 [PMID:24900463]
GtoPdb	-	-	5	pEC50	-	-	-	Biochem Biophys Res Commun (2002) 298: 714-9 [PMID:12419312]
GPBA receptor/G-protein coupled bile acid receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1255150] [GtoPdb: 37] [UniProtKB: Q80SS6]
ChEMBL	Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level	F	5.28	pIC50	5300	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 5718-5721 [PMID:20801037]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 infected in human erythrocytes assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting	F	4.7	pIC50	>20000	nM	IC50	MedChemComm (2017) 8: 1152-1157 [PMID:30108825]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]