ONO-4057 [Ligand Id: 6157] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL422420 (ONO-4057) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| BLT1 receptor/Leukotriene B4 receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722] | ||||||||
| ChEMBL | Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4. | B | 8.4 | pKi | 4 | nM | Ki | J Med Chem (1994) 37: 3327-3336 [PMID:7932560] |
| ChEMBL | Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand | B | 8.4 | pKi | 4 | nM | Ki | J Med Chem (1993) 36: 2703-2705 [PMID:8410983] |
| GtoPdb | - | - | 8.43 | pKi | 3.7 | nM | Ki | Prostaglandins (1992) 44: 261-75 [PMID:1332129] |
| ChEMBL | Compound was tested for inhibitory activity against human neutrophil LTB4 receptor binding | B | 8.43 | pKi | 3.7 | nM | Ki | J Med Chem (1996) 39: 2629-2654 [PMID:8709092] |
| GtoPdb | - | - | 6.15 | pIC50 | 700 | nM | IC50 | Prostaglandins (1992) 44: 261-75 [PMID:1332129] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
