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ChEMBL ligand: CHEMBL422420 (ONO-4057) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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BLT1 receptor/Leukotriene B4 receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722] | ||||||||
ChEMBL | Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4. | B | 8.4 | pKi | 4 | nM | Ki | J Med Chem (1994) 37: 3327-3336 [PMID:7932560] |
ChEMBL | Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand | B | 8.4 | pKi | 4 | nM | Ki | J Med Chem (1993) 36: 2703-2705 [PMID:8410983] |
GtoPdb | - | - | 8.43 | pKi | 3.7 | nM | Ki | Prostaglandins (1992) 44: 261-75 [PMID:1332129] |
ChEMBL | Compound was tested for inhibitory activity against human neutrophil LTB4 receptor binding | B | 8.43 | pKi | 3.7 | nM | Ki | J Med Chem (1996) 39: 2629-2654 [PMID:8709092] |
GtoPdb | - | - | 6.15 | pIC50 | 700 | nM | IC50 | Prostaglandins (1992) 44: 261-75 [PMID:1332129] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]