MDIP [Ligand Id: 6218] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL595840
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  • mGlu7 receptor/Metabotropic glutamate receptor 7 in Rat [ChEMBL: CHEMBL3879] [GtoPdb: 295] [UniProtKB: P35400]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
dCTP pyrophosphatase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769292] [UniProtKB: Q9H773]
ChEMBL Inhibition of full-length recombinant human dCTPase at by microtiter plate-adapted malachite green assay B 4 pIC50 >100000 nM IC50 Bioorg Med Chem Lett (2017) 27: 3219-3225 [PMID:28655422]
mGlu7 receptor/Metabotropic glutamate receptor 7 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879] [GtoPdb: 295] [UniProtKB: P35400]
GtoPdb - - 7.6 pIC50 26 nM IC50 J Pharmacol Exp Ther (2007) 323: 147-56 [PMID:17609420]
ChEMBL Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR F 7.7 pIC50 20 nM IC50 Bioorg Med Chem Lett (2010) 20: 726-729 [PMID:20005101]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]