NaHS [Ligand Id: 6278] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1644699 (Sodium Hydrogensulfide)
  • Carbonic anhydrase in Methanosarcina thermophila [ChEMBL: CHEMBL3932] [UniProtKB: P40881]
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  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
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  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
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  • TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Carbonic anhydrase in Methanosarcina thermophila (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3932] [UniProtKB: P40881]
ChEMBL Inhibition of Methanosarcina thermophila recombinant gamma-CA by CO2 hydration assay B 4.3 pKi 50000 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL Inhibition of archaeon Methanosarcina thermophila gamma-CA after 15 mins by stopped-flow/Co2 hydration assay B 4.3 pKi 50000 nM Ki Bioorg. Med. Chem. (2015) 23: 4405-4409 [PMID:26145820]
ChEMBL Inhibition of Methanosarcina thermophila recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method B 4.3 pKi 50000 nM Ki Bioorg Med Chem (2017) 25: 575-580 [PMID:27914949]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5 B 6.22 pKi 600 nM Ki Bioorg. Med. Chem. (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.3 B 6.22 pKi 600 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 3591-3595 [PMID:21570835]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay B 6.22 pKi 600 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 7142-7145 [PMID:23072866]
ChEMBL Inhibition of human recombinant wild type CA1 by stopped-flow CO2 hydration method B 6.22 pKi 600 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 256-260 [PMID:23200251]
ChEMBL Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay B 6.22 pKi 600 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 1636-1638 [PMID:23414807]
ChEMBL Inhibition of human carbonic anhydrase-1 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assay B 6.22 pKi 600 nM Ki Bioorg. Med. Chem. (2013) 21: 4472-4476 [PMID:23790722]
ChEMBL Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method B 6.22 pKi 600 nM Ki Bioorg. Med. Chem. Lett. (2014) 24: 4389-4396 [PMID:25168745]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5 B 4.4 pKi 40000 nM Ki Bioorg. Med. Chem. (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.3 B 4.4 pKi 40000 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 3591-3595 [PMID:21570835]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay B 4.4 pKi 40000 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 7142-7145 [PMID:23072866]
ChEMBL Inhibition of human recombinant wild type CA2 by stopped-flow CO2 hydration method B 4.4 pKi 40000 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 256-260 [PMID:23200251]
ChEMBL Inhibition of human cytosolic carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 hydration assay B 4.4 pKi 40000 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 1626-1630 [PMID:23414801]
ChEMBL Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay B 4.4 pKi 40000 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 1636-1638 [PMID:23414807]
ChEMBL Inhibition of human recombinant CA2 by CO2 hydration assay B 4.4 pKi 40000 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL Inhibition of human carbonic anhydrase-2 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assay B 4.4 pKi 40000 nM Ki Bioorg. Med. Chem. (2013) 21: 4472-4476 [PMID:23790722]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay B 4.4 pKi 40000 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay B 4.4 pKi 40000 nM Ki Bioorg. Med. Chem. Lett. (2014) 24: 1127-1132 [PMID:24461298]
ChEMBL Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method B 4.4 pKi 40000 nM Ki Bioorg. Med. Chem. Lett. (2014) 24: 4389-4396 [PMID:25168745]
ChEMBL Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method B 4.4 pKi 40000 nM Ki Bioorg. Med. Chem. Lett. (2014) 24: 4402-4406 [PMID:25168748]
ChEMBL Inhibition of human CA2 after 15 mins by stopped-flow/Co2 hydration assay B 4.4 pKi 40000 nM Ki Bioorg. Med. Chem. (2015) 23: 4405-4409 [PMID:26145820]
ChEMBL Inhibition of human carbonic anhydrase-2 by CO2 hydration reaction based colorimetric stopped-flow method B 4.4 pKi 40000 nM Ki Bioorg. Med. Chem. (2015) 23: 4831-4838 [PMID:26068018]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method B 4.4 pKi 40000 nM Ki Bioorg Med Chem (2017) 25: 575-580 [PMID:27914949]
ChEMBL Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition of CO2 hydration incubated for 15 mins prior to testing by stopped flow CO2 hydration method B 4.4 pKi 40000 nM Ki Bioorg Med Chem (2017) 25: 2010-2015 [PMID:28238511]
ChEMBL Inhibition of human CA2 incubated for 15 mins by stopped-flow CO2 hydration assay B 4.4 pKi 40000 nM Ki Bioorg Med Chem (2017) 25: 4800-4804 [PMID:28754318]
TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8]
GtoPdb Calcium imaging - 2.9 pEC50 - - - Eur. Urol. (2008) 53: 391-9 [PMID:18031925]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]