ChEMBL ligand: CHEMBL2179319 (JNJ-42153605)
mGlu2 receptor/Metabotropic glutamate receptor 2 in Human [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mGlu2 receptor/Metabotropic glutamate receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416]
GtoPdb	-	-	7.82	pKi	15	nM	Ki	J Med Chem (2012) 55: 8770-89 [PMID:23072213]
ChEMBL	Displacement of [3H]8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-phenyl-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine from mGlu2 receptor (unknown origin)	B	7.82	pKi	15	nM	Ki	J Med Chem (2016) 59: 8495-8507 [PMID:27579727]
ChEMBL	Binding affinity to human mGlu2R expressed in CHO cells by radioligand binding assay	B	7.82	pIC50	15	nM	IC50	J Med Chem (2012) 55: 8770-8789 [PMID:23072213]
ChEMBL	Positive allosteric modulation at human mGlu2 receptor W773A mutant expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting method	B	5	pEC50	>10000	nM	EC50	J Med Chem (2016) 59: 8495-8507 [PMID:27579727]
ChEMBL	Positive allosteric modulation at human mGlu2 receptor F643A mutant expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting method	B	6.41	pEC50	385	nM	EC50	J Med Chem (2016) 59: 8495-8507 [PMID:27579727]
ChEMBL	Agonist activity at human mGlu2R expressed in CHO cells	F	6.57	pEC50	270	nM	EC50	J Med Chem (2012) 55: 8770-8789 [PMID:23072213]
ChEMBL	Positive allosteric modulation at wild type human mGlu2 receptor L732A mutant expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect preincubated for 30 mins prior to glutamate challenge measured after 30 mins by [35S]GTP-gammaS binding assay	B	7.33	pEC50	46.4	nM	EC50	J Med Chem (2016) 59: 8495-8507 [PMID:27579727]
ChEMBL	Positive allosteric modulation at human mGlu2 receptor N735D mutant expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting method	B	7.57	pEC50	27	nM	EC50	J Med Chem (2016) 59: 8495-8507 [PMID:27579727]
ChEMBL	Positive allosteric modulation at human mGlu2 receptor F776A mutant expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting method	B	7.63	pEC50	23.6	nM	EC50	J Med Chem (2016) 59: 8495-8507 [PMID:27579727]
ChEMBL	Positive allosteric modulation of human mGlu2 receptor expressed in CHO cell membranes assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting method	B	7.77	pEC50	17	nM	EC50	J Med Chem (2016) 59: 8495-8507 [PMID:27579727]
ChEMBL	Positive allosteric modulator activity at human mGlu2R expressed in CHO cells incubated for 30 mins by [35S]GTPgammaS binding assay	F	7.77	pEC50	17	nM	EC50	J Med Chem (2012) 55: 8770-8789 [PMID:23072213]
GtoPdb	-	-	7.77	pEC50	17	nM	EC50	J Med Chem (2012) 55: 8770-89 [PMID:23072213]
ChEMBL	Positive allosteric modulation of wild-type human mGlu2 receptor expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting method	B	8.32	pEC50	4.8	nM	EC50	J Med Chem (2016) 59: 8495-8507 [PMID:27579727]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]