quinapril [Ligand Id: 6350] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1592 (C09AA06, Quinapril, CI-906)
  • Angiotensin-converting enzyme in Human [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
  • Angiotensin-converting enzyme in Rabbit [ChEMBL: CHEMBL4074] [UniProtKB: P12822]
  • Angiotensin-converting enzyme in Guinea pig [GtoPdb: 1613]
  • This target only has 0 pki data point
  • 0
1 CHEMBL1592_lig_chart_1 Angiotensin-converting enzyme HumanRabbitGuinea pig
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
ChEMBL Compound was tested for its inhibitory potency against angiotensin I converting enzyme. B 8.08 pIC50 8.3 nM IC50 J. Med. Chem. (1991) 34: 511-517 [PMID:1995872]
ChEMBL Inhibition of guinea pig angiotensin I converting enzyme B 8.08 pIC50 8.3 nM IC50 J. Med. Chem. (1986) 29: 1953-1961 [PMID:3020249]
ChEMBL Inhibitory activity against angiotensin I converting enzyme (ACE) B 8.08 pIC50 8.3 nM IC50 J. Med. Chem. (2000) 43: 305-341 [PMID:10669559]
ChEMBL In vitro inhibitory activity against Angiotensin I converting enzyme from unpurified guinea pig serum B 8.08 pIC50 8.3 nM IC50 J. Med. Chem. (1985) 28: 1291-1295 [PMID:2993618]
Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822]
ChEMBL DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) B 5.4 pIC50 4008 nM IC50 DrugMatrix in vitro pharmacology data
ChEMBL Inhibition of rabbit lung ACE assessed as hippuryl-histidyl-leucine hydrolysis after 30 mins by colorimetric method B 6.96 pIC50 110 nM IC50 Bioorg. Med. Chem. (2015) 23: 3526-3533 [PMID:25922179]
Angiotensin-converting enzyme in Guinea pig [GtoPdb: 1613]
GtoPdb - - 8.1 pIC50 8.3 nM IC50 Fed Proc (1984) 43: 1326-9 [PMID:6323223]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]