A-794278 [Ligand Id: 6354] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL225032
  • mGlu1 receptor/Metabotropic glutamate receptor 1 in Human [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
  • mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385]
  • This target only has 1 pki data point
  • 8.27
1 CHEMBL225032_lig_chart_1 Metabotropic glutamate receptor 1 HumanRat
There should be some charts here, you may need to enable JavaScript!
  • mGlu5 receptor/Metabotropic glutamate receptor 5 in Human [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594]
  • This target only has 0 pki data point
  • 0
2 CHEMBL225032_lig_chart_2 Metabotropic glutamate receptor 5 Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu1 receptor/Metabotropic glutamate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
GtoPdb - - 8 pIC50 10 nM IC50 J Med Chem (2005) 48: 7374-88 [PMID:16279797]
ChEMBL Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization F 9 pIC50 1 nM IC50 J. Med. Chem. (2005) 48: 7374-7388 [PMID:16279797]
mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385]
GtoPdb - - 8.27 pKi 5.4 nM Ki Eur J Pharmacol (2008) 580: 314-21 [PMID:18054908]
ChEMBL Inhibition of rat mGluR1 B 9 pIC50 1 nM IC50 Eur. J. Med. Chem. (2008) 43: 1025-1034 [PMID:17822809]
ChEMBL Inhibition of rat mGluR1 B 9 pIC50 1 nM IC50 Eur. J. Med. Chem. (2008) 43: 1025-1034 [PMID:17822809]
mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594]
ChEMBL Antagonist activity at human mGluR5 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization F 6.83 pIC50 147 nM IC50 J. Med. Chem. (2005) 48: 7374-7388 [PMID:16279797]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]