compound 10i [PMID: 23084894] [Ligand Id: 6365] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2205915
  • mGlu1 receptor/Metabotropic glutamate receptor 1 in Human [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
  • mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385]
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  • mGlu5 receptor/Metabotropic glutamate receptor 5 in Human [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu1 receptor/Metabotropic glutamate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
GtoPdb - - 8.22 pIC50 6 nM IC50 Bioorg Med Chem Lett (2012) 22: 7223-6 [PMID:23084894]
ChEMBL Antagonist activity at human mGluR1 F 8.22 pIC50 6 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 7223-7226 [PMID:23084894]
mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385]
ChEMBL Antagonist activity at rat mGluR1 F 7.84 pKi 14.5 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 7223-7226 [PMID:23084894]
mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594]
ChEMBL Antagonist activity at human mGluR5 F 5 pIC50 10000 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 7223-7226 [PMID:23084894]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]