VU-29 [Ligand Id: 6403] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL411221
  • mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
ChEMBL Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in HEK293 cells B 6.6 pKi 250 nM Ki J. Med. Chem. (2006) 49: 3332-3344 [PMID:16722652]
GtoPdb - - 6.61 pKi 244 nM Ki Mol Pharmacol (2007) 71: 1389-98 [PMID:17303702]
ChEMBL Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes F 7.97 pEC50 10.7 nM EC50 J. Med. Chem. (2006) 49: 3332-3344 [PMID:16722652]
GtoPdb - - 8.05 pEC50 9 nM EC50 Mol Pharmacol (2007) 71: 1389-98 [PMID:17303702]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]