VU0424465 [Ligand Id: 6411] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2431192 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
| GtoPdb | - | - | 6.77 | pEC50 | 171 | nM | EC50 | Biol Psychiatry (2013) 73: 501-9 [PMID:23140665] |
| ChEMBL | Positive allosteric modulation of rat mGluR5 stably expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4AM dye-based fluorescence assay | F | 8.31 | pEC50 | 4.9 | nM | EC50 | J Med Chem (2013) 56: 7976-7996 [PMID:24050755] |
| ChEMBL | Positive allosteric modulation of rat mGluR5 stably expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4AM dye-based fluorescence assay | F | 8.31 | pEC50 | 4.9 | nM | EC50 | J Med Chem (2013) 56: 7976-7996 [PMID:24050755] |
| GtoPdb | - | - | 8.82 | pEC50 | 1.5 | nM | EC50 | Biol Psychiatry (2013) 73: 501-9 [PMID:23140665] |
| ChEMBL | Positive allosteric modulation of rat mGluR5 | B | 8.82 | pEC50 | 1.5 | nM | EC50 | J Med Chem (2013) 56: 7976-7996 [PMID:24050755] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
