ChEMBL ligand: CHEMBL2431192
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
GtoPdb	-	-	6.77	pEC50	171	nM	EC50	Biol Psychiatry (2013) 73: 501-9 [PMID:23140665]
ChEMBL	Positive allosteric modulation of rat mGluR5 stably expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4AM dye-based fluorescence assay	F	8.31	pEC50	4.9	nM	EC50	J Med Chem (2013) 56: 7976-7996 [PMID:24050755]
ChEMBL	Positive allosteric modulation of rat mGluR5 stably expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4AM dye-based fluorescence assay	F	8.31	pEC50	4.9	nM	EC50	J Med Chem (2013) 56: 7976-7996 [PMID:24050755]
GtoPdb	-	-	8.82	pEC50	1.5	nM	EC50	Biol Psychiatry (2013) 73: 501-9 [PMID:23140665]
ChEMBL	Positive allosteric modulation of rat mGluR5	B	8.82	pEC50	1.5	nM	EC50	J Med Chem (2013) 56: 7976-7996 [PMID:24050755]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]