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ChEMBL ligand: CHEMBL2431192 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
GtoPdb | - | - | 6.77 | pEC50 | 171 | nM | EC50 | Biol Psychiatry (2013) 73: 501-9 [PMID:23140665] |
ChEMBL | Positive allosteric modulation of rat mGluR5 stably expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4AM dye-based fluorescence assay | F | 8.31 | pEC50 | 4.9 | nM | EC50 | J. Med. Chem. (2013) 56: 7976-7996 [PMID:24050755] |
ChEMBL | Positive allosteric modulation of rat mGluR5 stably expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4AM dye-based fluorescence assay | F | 8.31 | pEC50 | 4.9 | nM | EC50 | J. Med. Chem. (2013) 56: 7976-7996 [PMID:24050755] |
GtoPdb | - | - | 8.82 | pEC50 | 1.5 | nM | EC50 | Biol Psychiatry (2013) 73: 501-9 [PMID:23140665] |
ChEMBL | Positive allosteric modulation of rat mGluR5 | B | 8.82 | pEC50 | 1.5 | nM | EC50 | J. Med. Chem. (2013) 56: 7976-7996 [PMID:24050755] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]