VU0424465 [Ligand Id: 6411] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL2431192
  • mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
GtoPdb - - 6.77 pEC50 171 nM EC50 Biol Psychiatry (2013) 73: 501-9 [PMID:23140665]
ChEMBL Positive allosteric modulation of rat mGluR5 stably expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4AM dye-based fluorescence assay F 8.31 pEC50 4.9 nM EC50 J. Med. Chem. (2013) 56: 7976-7996 [PMID:24050755]
ChEMBL Positive allosteric modulation of rat mGluR5 stably expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4AM dye-based fluorescence assay F 8.31 pEC50 4.9 nM EC50 J. Med. Chem. (2013) 56: 7976-7996 [PMID:24050755]
GtoPdb - - 8.82 pEC50 1.5 nM EC50 Biol Psychiatry (2013) 73: 501-9 [PMID:23140665]
ChEMBL Positive allosteric modulation of rat mGluR5 B 8.82 pEC50 1.5 nM EC50 J. Med. Chem. (2013) 56: 7976-7996 [PMID:24050755]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]