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ChEMBL ligand: CHEMBL1682799 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] | ||||||||
ChEMBL | Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilization | F | 7.3 | pEC50 | 50 | nM | EC50 | Bioorg. Med. Chem. Lett. (2011) 21: 1350-1353 [PMID:21315585] |
ChEMBL | Positive allosteric modulation of human mGlu4 receptor expressed in human HEK293 cells assessed as potentiation of glutamate-induced calcium mobilization after 1 hr by FLIPR assay | F | 7.35 | pEC50 | 44.67 | nM | EC50 | Bioorg. Med. Chem. Lett. (2011) 21: 1402-1406 [PMID:21295468] |
ChEMBL | Positive allosteric modulation of human mGlu4 receptor expressed in human HEK293 cells assessed as potentiation of glutamate-induced calcium mobilization after 1 hr by FLIPR assay | F | 7.35 | pEC50 | 44.3 | nM | EC50 | Bioorg. Med. Chem. Lett. (2011) 21: 1402-1406 [PMID:21295468] |
mGlu5 receptor in Rat [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
GtoPdb | - | - | 7.41 | pEC50 | 39 | nM | EC50 | Mol Pharmacol (2012) 81: 120-33 [PMID:22021324] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]