compound 8 [PMID: 20598884] [Ligand Id: 6436] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1209201 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
| GtoPdb | - | - | 6.99 | pKi | 102 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 4390-4 [PMID:20598884] |
| ChEMBL | Displacement of [3H]methoxy-PEPy from rat mGlu5 receptor expressed in HEK293A cells after 60 mins by scintillation counting | B | 6.99 | pKi | 102 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 4390-4394 [PMID:20598884] |
| ChEMBL | Antagonist activity at rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization | F | 7.23 | pIC50 | 59 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4390-4394 [PMID:20598884] |
| GtoPdb | - | - | 7.23 | pIC50 | 59 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4390-4 [PMID:20598884] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
