compound 8 [PMID: 20598884] [Ligand Id: 6436] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1209201
  • mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
GtoPdb - - 6.99 pKi 102 nM Ki Bioorg Med Chem Lett (2010) 20: 4390-4 [PMID:20598884]
ChEMBL Displacement of [3H]methoxy-PEPy from rat mGlu5 receptor expressed in HEK293A cells after 60 mins by scintillation counting B 6.99 pKi 102 nM Ki Bioorg. Med. Chem. Lett. (2010) 20: 4390-4394 [PMID:20598884]
ChEMBL Antagonist activity at rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization F 7.23 pIC50 59 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 4390-4394 [PMID:20598884]
GtoPdb - - 7.23 pIC50 59 nM IC50 Bioorg Med Chem Lett (2010) 20: 4390-4 [PMID:20598884]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]