compound 23 [PMID: 17590335] [Ligand Id: 6444] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL232188
  • mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
ChEMBL Displacement of [3H]MPEP from mGlu5 receptor in rat brain B 7.66 pKi 22 nM Ki Bioorg. Med. Chem. Lett. (2007) 17: 4415-4418 [PMID:17590335]
GtoPdb - - 7.66 pKi 22 nM Ki Bioorg Med Chem Lett (2007) 17: 4415-8 [PMID:17590335]
ChEMBL Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay F 9.1 pIC50 0.8 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 4415-4418 [PMID:17590335]
GtoPdb - - 9.1 pIC50 0.8 nM IC50 Bioorg Med Chem Lett (2007) 17: 4415-8 [PMID:17590335]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]