fasidotrilat [Ligand Id: 6502] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL325055
1 CHEMBL325055_lig_chart_1 Angiotensin-converting enzyme Human
There should be some charts here, you may need to enable JavaScript!
  • Neutral endopeptidase in Human [GtoPdb: 1611] [UniProtKB: P08473]
  • Neutral endopeptidase/Neprilysin in Rat [ChEMBL: CHEMBL3369] [GtoPdb: 1611] [UniProtKB: P07861]
  • 8.25
2 CHEMBL325055_lig_chart_2 Neutral endopeptidase HumanRat
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
GtoPdb - - 8 pKi 9.8 nM Ki Med Chem (2005) 1: 71-104 [PMID:16789888]
ChEMBL Inhibitory activity against angiotensin I converting enzyme (ACE) B 8.01 pKi 9.8 nM Ki J. Med. Chem. (2000) 43: 305-341 [PMID:10669559]
Neutral endopeptidase in Human [GtoPdb: 1611] [UniProtKB: P08473]
GtoPdb - - 8.3 pKi 5.6 nM Ki Med Chem (2005) 1: 321-6 [PMID:16789889]
Neutral endopeptidase/Neprilysin in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3369] [GtoPdb: 1611] [UniProtKB: P07861]
ChEMBL Inhibitory activity against neutral Endopeptidase B 8.25 pKi 5.6 nM Ki J. Med. Chem. (2000) 43: 305-341 [PMID:10669559]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]