Nωpropyl-L-arginine [Ligand Id: 6525] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL107528
  • NG,NG-Dimethylarginine dimethylaminohydrolase 1/N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 in Human [ChEMBL: CHEMBL6036] [GtoPdb: 1247] [UniProtKB: O94760]
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  • Neuronal NOS/Nitric-oxide synthase, brain in Rat [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
NG,NG-Dimethylarginine dimethylaminohydrolase 1/N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6036] [GtoPdb: 1247] [UniProtKB: O94760]
ChEMBL Inhibition of human DDAH1 by plate-reader assay B 4.05 pKi 90000 nM Ki Bioorg. Med. Chem. (2008) 16: 10205-10209 [PMID:19013076]
Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476]
ChEMBL Inhibition of rat nNOS B 6.26 pKi 550 nM Ki J. Med. Chem. (2013) 56: 3121-3147 [PMID:23458846]
GtoPdb - - 7.2 pKi - - - J. Med. Chem. (1997) 40: 3869-70 [PMID:9397167]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]