264W94 [Ligand Id: 6529] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL332370 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Sodium/bile acid and sulphated solute cotransporter 2/Ileal bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908] | ||||||||
| ChEMBL | Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis | B | 6.74 | pIC50 | 180 | nM | IC50 | J Med Chem (2013) 56: 5094-5114 [PMID:23678871] |
| ChEMBL | In vitro inhibitory activity against uptake of [14C]taurocholate in baby hamster kidney cells transfected with cDNA from human Apical Sodium-Codependent Bile Acid Transporter | B | 7.32 | pIC50 | 48 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3727-3730 [PMID:14552767] |
| GtoPdb | - | - | 7.32 | pIC50 | 48 | nM | IC50 |
Bioorg Med Chem Lett (2003) 13: 3727-30 [PMID:14552767]; J Med Chem (2013) 56: 5094-114 [PMID:23678871] |
| Sodium/bile acid and sulphated solute cotransporter 2 in Human [GtoPdb: 960] [UniProtKB: Q12908] | ||||||||
| GtoPdb | - | - | 7.32 | pIC50 | 48 | nM | IC50 |
Bioorg Med Chem Lett (2003) 13: 3727-30 [PMID:14552767]; J Med Chem (2013) 56: 5094-114 [PMID:23678871] |
| Sodium/bile acid and sulphated solute cotransporter 2/Ileal sodium/bile acid cotransporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073708] [GtoPdb: 960] [UniProtKB: P70172] | ||||||||
| ChEMBL | Inhibition of mouse ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2013) 56: 5094-5114 [PMID:23678871] |
| Sodium/bile acid and sulphated solute cotransporter 2/Ileal sodium/bile acid cotransporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073686] [GtoPdb: 960] [UniProtKB: Q62633] | ||||||||
| ChEMBL | Inhibition of rat ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis | B | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (2013) 56: 5094-5114 [PMID:23678871] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
