264W94 [Ligand Id: 6529] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL332370 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Sodium/bile acid and sulphated solute cotransporter 2/Ileal bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908] | ||||||||
| ChEMBL | Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis | B | 6.74 | pIC50 | 180 | nM | IC50 | J Med Chem (2013) 56: 5094-5114 [PMID:23678871] |
| ChEMBL | In vitro inhibitory activity against uptake of [14C]taurocholate in baby hamster kidney cells transfected with cDNA from human Apical Sodium-Codependent Bile Acid Transporter | B | 7.32 | pIC50 | 48 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3727-3730 [PMID:14552767] |
| GtoPdb | - | - | 7.32 | pIC50 | 48 | nM | IC50 |
Bioorg Med Chem Lett (2003) 13: 3727-30 [PMID:14552767]; J Med Chem (2013) 56: 5094-114 [PMID:23678871] |
| Sodium/bile acid and sulphated solute cotransporter 2 in Human [GtoPdb: 960] [UniProtKB: Q12908] | ||||||||
| GtoPdb | - | - | 7.32 | pIC50 | 48 | nM | IC50 |
Bioorg Med Chem Lett (2003) 13: 3727-30 [PMID:14552767]; J Med Chem (2013) 56: 5094-114 [PMID:23678871] |
| Sodium/bile acid and sulphated solute cotransporter 2/Ileal sodium/bile acid cotransporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073708] [GtoPdb: 960] [UniProtKB: P70172] | ||||||||
| ChEMBL | Inhibition of mouse ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2013) 56: 5094-5114 [PMID:23678871] |
| Sodium/bile acid and sulphated solute cotransporter 2/Ileal sodium/bile acid cotransporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073686] [GtoPdb: 960] [UniProtKB: Q62633] | ||||||||
| ChEMBL | Inhibition of rat ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis | B | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (2013) 56: 5094-5114 [PMID:23678871] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
