264W94 [Ligand Id: 6529] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL332370
  • Sodium/bile acid and sulphated solute cotransporter 2/Ileal bile acid transporter in Human [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908]
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  • Sodium/bile acid and sulphated solute cotransporter 2 in Human [GtoPdb: 960] [UniProtKB: Q12908]
  • Sodium/bile acid and sulphated solute cotransporter 2/Ileal sodium/bile acid cotransporter in Mouse [ChEMBL: CHEMBL2073708] [GtoPdb: 960] [UniProtKB: P70172]
  • Sodium/bile acid and sulphated solute cotransporter 2/Ileal sodium/bile acid cotransporter in Rat [ChEMBL: CHEMBL2073686] [GtoPdb: 960] [UniProtKB: Q62633]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Sodium/bile acid and sulphated solute cotransporter 2/Ileal bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908]
ChEMBL Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis B 6.74 pIC50 180 nM IC50 J Med Chem (2013) 56: 5094-5114 [PMID:23678871]
ChEMBL In vitro inhibitory activity against uptake of [14C]taurocholate in baby hamster kidney cells transfected with cDNA from human Apical Sodium-Codependent Bile Acid Transporter B 7.32 pIC50 48 nM IC50 Bioorg Med Chem Lett (2003) 13: 3727-3730 [PMID:14552767]
GtoPdb - - 7.32 pIC50 48 nM IC50 Bioorg Med Chem Lett (2003) 13: 3727-30 [PMID:14552767];
J Med Chem (2013) 56: 5094-114 [PMID:23678871]
Sodium/bile acid and sulphated solute cotransporter 2 in Human [GtoPdb: 960] [UniProtKB: Q12908]
GtoPdb - - 7.32 pIC50 48 nM IC50 Bioorg Med Chem Lett (2003) 13: 3727-30 [PMID:14552767];
J Med Chem (2013) 56: 5094-114 [PMID:23678871]
Sodium/bile acid and sulphated solute cotransporter 2/Ileal sodium/bile acid cotransporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073708] [GtoPdb: 960] [UniProtKB: P70172]
ChEMBL Inhibition of mouse ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis B 8.52 pIC50 3 nM IC50 J Med Chem (2013) 56: 5094-5114 [PMID:23678871]
Sodium/bile acid and sulphated solute cotransporter 2/Ileal sodium/bile acid cotransporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073686] [GtoPdb: 960] [UniProtKB: Q62633]
ChEMBL Inhibition of rat ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis B 7.66 pIC50 22 nM IC50 J Med Chem (2013) 56: 5094-5114 [PMID:23678871]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]