KGP94 [Ligand Id: 6533] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1269632
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858]
ChEMBL Inhibition of human liver cathepsin B after 5 mins by microplate reader analysis B 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 6610-6615 [PMID:20933415]
cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711]
ChEMBL Covalent/reversible inhibition of human liver cathepsin-L using Z-FR-AMC as substrate preincubated for 5 mins followed by substrate addition measured at 15 sec interval for 5 mins by Morrison's equation analysis B 8.43 pKi 3.7 nM Ki Bioorg Med Chem Lett (2017) 27: 1304-1310 [PMID:28117205]
ChEMBL Inhibition of human liver cathepsin L after 5 mins by microplate reader analysis B 6.88 pIC50 131.4 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 6610-6615 [PMID:20933415]
GtoPdb - - 6.9 pIC50 131.4 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 6610-5 [PMID:20933415]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]