DG-051 [Ligand Id: 6548] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL565789
  • Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960]
  • This target only has 0 pki data point
  • 0
1 CHEMBL565789_lig_chart_1 Leukotriene A4 hydrolase Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960]
ChEMBL Binding affinity to human recombinant LTA4H by isothermal calorimetry B 7.6 pKd 25 nM Kd J. Med. Chem. (2010) 53: 573-585 [PMID:19950900]
GtoPdb - - 7.3 pIC50 47 nM IC50 J Med Chem (2010) 53: 573-85 [PMID:19950900]
ChEMBL Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MS B 7.33 pIC50 47 nM IC50 J. Med. Chem. (2010) 53: 573-585 [PMID:19950900]
ChEMBL Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISA B 7.43 pIC50 37 nM IC50 J. Med. Chem. (2010) 53: 573-585 [PMID:19950900]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]